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Expert diagnosis
Marfan clinic is largest in Midwest
Sept. 17,
2009 -- Marfan syndrome is almost as common as cystic fibrosis or muscular dystrophy, but doctors sometimes miss its signature traits that include unusual height, long, spindly arms, legs and fingers, a sunken chest and loose jointedness. To improve diagnosis, physicians at the School of Medicine and Barnes-Jewish Hospital have established the Marfan Clinic, which has quickly become the largest multidisciplinary in the Midwest for Marfans and related syndromes.
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The skinny on fat
Fat in the liver -- not the belly -- is a better marker for disease risk
Aug. 24,
2009 -- New findings from nutrition researchers at the School of Medicine suggest that it's not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver. They report online in the journal PNAS Early Edition that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body's ability to metabolize sugar.
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Diabetics need D -- the vitamin
Research shows why low vitamin D raises heart disease risks in diabetics
Aug. 21,
2009 -- Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and now researchers at the School of Medicine think they know why. They have found that diabetics deficient in vitamin D can't process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke.
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Food therapy
Food additive may one day help control blood lipids and reduce disease risk
July 30,
2009 -- Scientists at the School of Medicine have identified a substance in the liver that helps process fat and glucose. That substance is a component of the common food additive lecithin, and researchers speculate it may one day be possible to use lecithin products to control blood lipids and reduce risk for diabetes, hypertension or cardiovascular disease using treatments delivered in food rather than medication.
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Key leadership position
Dorn named Needleman Professor
July 9,
2009 --
Gerald W. Dorn II has been named the Philip and Sima K. Needleman Professor of Medicine at the School of Medicine. The professorship was established to support a faculty member holding a key leadership position within the BioMed 21 initiative, a multidisciplinary imperative to rapidly convert research findings into effective, individualized treatments.
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Heart valve 'redo'
Four out of 106 heart replacement valves from pig hearts failed
June 29,
2009 -- Pig heart valves used to replace defective aortic valves in human patients failed much earlier and more often than expected, says a report from cardiac surgeons at the School of Medicine. This is the first report to demonstrate this potential problem, the researchers say.
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A pacemaker for blood pressure?
Researchers evaluate iPod-sized device for hard-to-treat high blood pressure
May 27,
2009 --
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| Similar to a pacemaker, the iPod-sized device is implanted under the skin near the collarbone. |
Some 15 million Americans have high blood pressure that can't be controlled with medication, leaving them at high risk for early death, stroke, heart disease or kidney failure. Researchers at the School of Medicine are evaluating whether an investigational device can help these patients keep their blood pressure in check.
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Anticipation can shift brainwaves
Changing brainwave pattern puts eyes on alert for visual stimuli
May 19,
2009 -- When people look for something to pop into view at a particular spot—a baseball batter looking to a pitcher, for example—evidence has suggested that the visual centers of the brain can prepare themselves to respond more quickly and efficiently when the anticipated stimulus appears. Now researchers have provided experimental confirmation of how this happens: a shift in the brainwave patterns in the visual cortex.
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High-tech miniature medicine
Nanoparticles help detect disease and deliver drugs with pinpoint accuracy
April 21,
2009 -- Researchers at Washington University School of Medicine in St. Louis are studying military-like techniques to detect and destroy deadly pathogens, including cancerous tumors. Nanoparticles, invisible to the human eye, operate much like a laser-guided missile within the body. They are able to locate and even deliver medication directly to diseased areas with great accuracy in the laboratory. The researchers will soon begin testing the nanoparticles in human clinical trials.
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CRUSADE to help heart attack patients
New tool calculates risk of bleeding in heart attack patients
April 14,
2009 -- With eight basic medical facts in hand, doctors can now estimate the risk of bleeding for a patient having a heart attack. Using clinical variables, researchers at the School of Medicine, Duke University and collaborating institutions have created a new method to estimate bleeding risk and help lessen the chances that heart attack patients will experience this common complication.
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