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Precious gift

Grad student's kidney gives life to stranger

March 9, 2009 -- Last year, Chuck Rickert, a fifth-year student in the M.D./Ph.D. program at the School of Medicine, heard a show about kidney donation on National Public Radio's "Talk of the Nation." One of the callers, a man in his 50s on dialysis, said his blood type did not match any friends or family, and his only option for a new kidney was to wait for something bad to happen to a younger person. The distressed man's call stuck with Rickert, who eventually decided to anonymously donate one of his own kidneys.


Igniting a recall

Quick thinking by WUSM physician leads to international investigation

May 1, 2008 -- In early January, two patients undergoing kidney dialysis at St. Louis Children's Hospital had sudden life-threatening allergic reactions that caused their eyes, lips and tongues to swell, raised their heart rates and dropped their blood pressures dangerously low. After the dialysis staff treated the children with medication that relieved the symptoms, they called infectious diseases specialist Alexis Elward, who sprung into action to help determine the cause. Little did she know it would spark an international investigation into a common blood thinner and a recall of the drug from the market.


Avoiding vascular calcification

Readily available treatment could help prevent heart disease in kidney patients

April 17, 2008 -- The estimated 19 million Americans living with chronic kidney disease (CKD) face a high risk of death from cardiovascular disease, usually related to high levels of blood phosphate. Now researchers at the School of Medicine have demonstrated that high blood phosphate directly stimulates calcification of blood vessels and that phosphate-binding drugs can decrease vascular calcification.


Fighting a 'devastating illness'

$5.7 million to fund new kidney disease research center

Aug. 6, 2007 -- A $5.7 million grant will establish a new center for kidney disease research at the School of Medicine. Directed by Marc R. Hammerman, the Chromalloy Professor of Renal Diseases in Medicine, the center will investigate the underlying causes of kidney disease to speed the development of new treatments. The center's funding comes from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), one of the National Institutes of Health (NIH).


Indebted donors

Researchers study reimbursing living organ donors for out-of-pocket expenses

Nov. 9, 2006 --
More than 80,000 people in the United States are on waiting lists for organ transplants. Some will have to wait for the death of a matching donor, but more and more people are receiving organs from living donors. In an effort to close the gap between organ supply and demand, researchers at Washington University School of Medicine, the University of Michigan and the American Society of Transplant Surgeons are studying ways to reimburse living donors for some of their out-of-pocket expenses when they choose to donate an organ.


Fighting kidney rejection

Antibody reduces acute rejection in high-risk kidney transplant patients

Nov. 8, 2006 -- Nearly 70 percent of kidney transplant patients get short-term drug therapy initially administered during surgery to help prevent rejection. In the first head-to-head comparison of the two drugs most commonly given to ward off acute kidney rejection, an international study led by researchers at Washington University School of Medicine in St. Louis shows that one - anti-thymocyte globulin - is superior.


Insight into kidney failure

Keep the baby, toss the bathwater: How kidneys retain proteins, discard waste

Aug. 1, 2006 -- New research may finally settle a decades-old debate about how the kidney keeps valuable blood proteins from harmfully slipping into the urine, a serious health symptom that often precedes kidney failure. WUSM scientists discovered that a structure, known as the glomerular basement membrane, plays a key role in the process.


Genetic culprit identified

Scientists solve 30-year-old mystery of mutant mouse's kidney woes

May 1, 2006 -- Researchers seeking insights into kidney failure in human infants have located the source of a 30-year-old mystery mutation that causes similar problems in a mouse line.


Alone at the helm

One-of-a-kind doctor guides kidney transplant program in right direction

April 24, 2006 --
Brennan reviews patient results with nurse Anita Williams.
Photo by Robert Boston
Brennan reviews patient results with nurse Anita Williams.
Since 1993, Daniel Brennan has been the sole full-time faculty member at the School of Medicine in the area of transplant nephrology. During that time, the number of kidney transplants performed each year at Barnes-Jewish Hospital has doubled, and the rejection rate has dropped from about 50 percent to less than 5 percent.


Multitasking organ

Links between kidneys, bones can put deadly strain on heart

Dec. 20, 2005 --
Multitasking might seem like a modern invention, but in biology it's been an established technique for millennia. The organs of the human body all have their well-known primary specialties, but many of them also play secondary roles in support of each other. One such moonlighter is the human kidney, which purifies waste from the blood, but also has a more recently identified role as a contributor to the structural integrity of the human skeleton.



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Media Assistance:

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Senior Medical Sciences Writer
purdym@wustl.edu

(314) 286-0122
Related Links:
Renal Division
National Institute of Diabetes and Digestive and Kidney Diseases

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Revised:

Wednesday, July 6, 2005


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