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Smoking / Lung / Asthma
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Reassuring results
Against expectations, genetic variation does not alter asthma treatment response
Nov. 19,
2009 -- Studies have suggested that asthma patients with a specific genetic variation might not respond as well to certain treatments as those with a different variation. But a new study in this week's edition of The Lancet shows that patients with either variation respond to combination treatment, and that this treatment should be continued, School of Medicine researchers report.
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The atopic march
Researchers discover why eczema often leads to asthma
May 18,
2009 --
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| Top: normal lungs. Bottom: asthmatic lungs. |
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Many young children who get a severe skin rash develop asthma months or years later. Doctors call the progression from eczema, or atopic dermatitis, to breathing problems the atopic march. Now scientists at the School of Medicine have uncovered what might be the key to atopic march. They've shown that a substance secreted by damaged skin circulates through the body and triggers asthmatic symptoms in allergen-exposed laboratory mice.
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Drug-free treatment for uncontrollable asthma
New procedure alleviates symptoms in people with severe asthma
May 18,
2009 -- A new drug-free treatment for asthma has been shown to be effective in an international study of patients with severe, uncontrolled asthma. The results showed statistically significant improvements in quality of life and reductions in asthma attacks and emergency room visits for patients who underwent the treatment.
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Asthma testing
Washington University physicians provide free asthma screening at Science Center
May 11,
2009 -- If you've regularly been coughing, wheezing or short of breath, you may want to get tested for asthma at the Saint Louis Science Center on Saturday, May 16, 2009. As part of a nationwide program, Washington University School of Medicine physicians will be at the Science Center to test lung function and answer questions about asthma. The screenings are free.
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Life lessons from an asthma coach
Asthma coaching can reduce hospitalizations in some children
May 4,
2009 -- Working with an asthma coach helps to significantly reduce hospitalizations of low-income, African-American children with asthma, results of a new, two-year study show. Researchers at the School of Medicine and the University of North Carolina at Chapel Hill worked with nearly 200 parents of children between 2-8 years old on Medicaid who had been hospitalized for asthma at St. Louis Children's Hospital.
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Personalized asthma care
Children's characteristics may determine response to asthma drug
May 4,
2009 -- Certain characteristics of preschool-aged children at high risk for asthma could help physicians deliver more personalized and effective treatment. Researchers at the School of Medicine and five other sites nationwide found that children who showed the most improvement in days without wheezing using an inhaled corticosteroid drug were caucasian boys who had allergies and had a hospitalization or emergency department visit for asthma symptoms in the year prior to the trial.
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Gene's link to cancer revealed
Genetic source of rare childhood cancer found; gene is implicated in other cancers
April 20,
2009 -- The search for the cause of an inherited form of a rare, aggressive childhood lung cancer has uncovered important information about how the cancer develops and potentially sheds light on the development of other cancers. The finding by researchers at the School of Medicine and other collaborating institutions adds the final link to the chain connecting the gene DICER1to cancer development.
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Mild acid reflux not an asthma cause
Heartburn medications do not ease asthma symptoms
April 8,
2009 -- The predominance of heartburn among asthma sufferers led many specialists to suspect that acid reflux could be a trigger for the coughing, wheezing and breathlessness of asthma. In fact, it has become standard practice to prescribe heartburn medication to people with poorly controlled asthma, even if they don't have overt acid reflux symptoms. But a new study shows that heartburn medication does not help control asthma symptoms.
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Steroids for asthma
Asthma drugs need to be maintained for continued benefit
Feb. 17,
2009 -- Children whose asthma improved while taking steroid drugs for several years did not see those improvements continue after stopping the drugs, new results from a comprehensive childhood asthma study show. The results come from the Childhood Asthma Management Program (CAMP) clinical trial, in which more than 1,000 children age 5-12 were treated for mild to moderate asthma over more than four years.
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Vaccinating against lung cancer
Lung cancer vaccine to be evaluated at Siteman Cancer Center
Dec. 9,
2008 -- A vaccine designed to prevent the recurrence of lung cancer is now being tested in centers around the world including the Siteman Cancer Center at the School of Medicine and Barnes-Jewish Hospital. The vaccine stimulates the immune system to destroy cells that carry a tumor-specific antigen called MAGE-A3. This antigen is not present in normal tissue but is found in several cancer types, including 35 percent to 50 percent of cases of the most common type of lung cancer, non-small cell lung cancer.
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