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Allergy / Immunology


News Stories & Tip Sheets:

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Igniting a recall

Quick thinking by WUSM physician leads to international investigation

May 1, 2008 -- In early January, two patients undergoing kidney dialysis at St. Louis Children's Hospital had sudden life-threatening allergic reactions that caused their eyes, lips and tongues to swell, raised their heart rates and dropped their blood pressures dangerously low. After the dialysis staff treated the children with medication that relieved the symptoms, they called infectious diseases specialist Alexis Elward, who sprung into action to help determine the cause. Little did she know it would spark an international investigation into a common blood thinner and a recall of the drug from the market.


Preventing asthma

Blocking effects of viral infections may prevent asthma in young children

Nov. 6, 2007 --
Normal lung air passage (left) and asthmatic lung air passage after viral infection
Normal lung air passage (left) and asthmatic lung air passage after viral infection
Babies who get severe respiratory viral infections are much more likely to suffer from asthma as they get older. Now researchers at the School of Medicine have pinpointed a key step in the development of asthma in mice after a severe respiratory infection. They suggest that medications designed to interfere with this mechanism could potentially prevent many cases of childhood asthma.


'Clinician at heart'

Bedside to bench and back

Oct. 12, 2007 --
Photo by Dilip Vishwanat
Thomas Ferkol Jr. gives patient Carli Kasten a chance to listen to his heart and lungs before he listens to hers.
Growing up in northeastern Ohio, Thomas Ferkol Jr. lived among the Old-Order Amish communities. When he was young, his father taught physical education and art in a small school system in Geauga County, where many of his students were Amish. As an unexpected twist, Ferkol, a pediatric physician-scientist working on cystic fibrosis and other lung diseases in children, has found through patients he treats at St. Louis Children's Hospital that a rare genetic lung disease is common in Amish and Mennonite populations.



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Faculty Experts:

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Stanford Peng

Assistant professor of internal medicine

Peng is working to uncover the molecular and genetic underpinnings of autoimmune conditions such as lupus, inflammatory bowel disease and some forms of arthritis. His lab was the first to find firm experimental evidence supporting a radical new theory for what immune cells are like when they're not ...


Expertise: lupus, arthritis, inflammatory bowel disease, T cell, B cell, immunology, autoimmunity

Media assistance: (314) 286-0122 / purdym@wustl.edu


John Morris

Director and Principal Investigator, Alzheimer's Disease Research Center, Department of Neurology

John Morris
Morris
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John C. Morris, M.D., is the Harvey A. and Dorismae Hacker Friedman Distinguished Professor of Neurology, Professor of Pathology and Immunology and of Physical Therapy, and the Director of the Alzheimer Disease Research Center, Center for Aging, the Memory and Aging Project, and the Memory Diagnostic ...


Expertise: Alzheimer's disease, dementia, memory, aging, mild cognitive impairment

Media assistance: (314) 286-0122 / purdym@wustl.edu


Roy Curtiss

Professor emeritus of biology in Arts & Sciences

Roy Curtiss
Roy Curtiss
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Has developed a Salmonella-based oral vaccine for livestock that can free animals from the virulent strain of Salmonella that causes food-poisoning in humans. His vaccine has received FDA approval for swine and poultry and is on the market. Curtiss also has obtained patents for the use of transgenic ...


Expertise: Salmonella, food poisoning, FDA, vaccine, genetic engineering, microbial, pathogen, …

Direct contact: (314) 935-6819 / rcurtiss@wustl.edu


Robert Schreiber

Alumni Endowed Professor of Pathology and Immunology

Our research is aimed at elucidating the molecular cell biology of cytokine receptor signaling and in defining the effects of signaling dysfunction on tumor development. Towards these ends, we are studying the receptors for interferon-gamma (IFNg) and interleukin-10 (IL-10), two related yet distinct ...


Expertise: Tumor immunology; immune system/response

Media assistance: (314) 286-0141 / ericsong@wustl.edu


Steven Teitelbaum

Wilma and Roswell Messing Professor of Pathology and Immunology

Teitelbaum
Teitelbaum

As the past president of the Federation of American Societies for Experimental Biology — the largest coalition of biomedical research associations in the United States — Teitelbaum is a strong supporter for therapeutic cloning. Somatic cell nuclear transfer, as it is also known, could hold the potential ...


Expertise: Experimental biology, therapeutic cloning, osteoporosis, bone degeneration, bone disease

Media assistance: (314) 286-0120 / westerhousej@wustl.edu



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Related News Clips:

Showing 4 Clips.
Camel antibodies aid caffeine test
The Arizona Republic online

July 6, 2006 -- A caffeine detection test developed by WUSTL medical researchers will help people know if their drinks include caffeine.
WUSTL senior scientist Dan Crimmins comments.


A controversial therapy for diabetes is verified
The New York Times, Wall Street Journal, St. Louis Post-Dispatch and 47 others

March 24, 2006 -- Three groups of scientists -- at U Chicago, WUSTL and Harvard -- reported in Science that they independently replicated a controversial finding: severely diabetic mice can recover on their own if researchers squelch an immune system attack that is causing the disease.
It is a discovery that was first published in 2001 and raised the hopes of people with Type 1 diabetes.
The findings also gave rise to questions about using embryonic stem cells as replacement cells for diabetics.
The Post-Dispatch article includes comments from WUSTL immunologist Emil Unanue.


Drug holds hope for some with tough cases of asthma
St. Louis Post-Dispatch and 19 others

May 24, 2005 -- Report on a study conducted by WUSTL and SLU researchers on behalf of drug maker Novartis Pharmaceuticals to test a new therapy against poorly controlled asthma. WUSTL researcher Phillip Korenblat and WUSTL allergy and immunology division chief James Wedner comment.


University first to grow common food poisoning cause in lab
Associated Press State & Local Wire, St. Louis Post-Dispatch and 26 others

Nov. 30, 2004 -- School of Medicine researchers are the first to grow a common cause of diarrhea, vomiting and other stomach problems in a lab, a move that could potentially speed along development of a vaccine. Lead researcher Skip Virgin comments.



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Related Information
Media Assistance:

Jim Dryden
Assoc. Dir. of Broadcast Services
jdryden@wustl.edu

(314) 286-0110
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Revised:

Thursday, Dec. 2, 2004


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