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Bone & Mineral Diseases
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Treating bone and muscle disorders
Grant creates new Center for Musculoskeletal Biology and Medicine
June 9,
2009 -- A five-year, $3 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), will allow investigators from more than 50 School of Medicine laboratories to join forces in the fight against musculoskeletal disorders. The grant funds a Core Center for Musculoskeletal Biology and Medicine. Its goal is to better understand causes and potential treatments for muscle and bone disorders.
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Bone density benefit
Bone drug could help prevent the spread of breast cancer
May 15,
2008 -- Maintaining bone density could be a key to decreasing the spread of cancer in women with locally advanced breast cancer, according to research at the School of Medicine. Bones are common sites for the spread, or metastasis, of breast cancer. Scientists here found that women treated for stage II/III breast cancer who also received a bone strengthening drug were less likely to have breast tumor cells growing in their bones after three months.
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Better bones
Potential osteoporosis treatment could help patients fortify their bones
Feb. 24,
2008 -- A better drug for osteoporosis wouldn't just preserve patients' old bone structure; it would help fortify their weakened bones with new bone material. Such a drug could be on the horizon because of research at the School of Medicine that has uncovered new information about how to amplify the bone formation process.
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Your Disease Risk
Siteman Cancer Center unveils web tool for estimating risk of five major diseases
June 28,
2007 --
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| Graham Colditz and the Your Disease Risk Web site |
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A few clicks of the mouse tell visitors to the "Your Disease Risk" Web site their risk for cancer, heart disease, diabetes, stroke and osteoporosis. The Siteman Cancer Center at the School of Medicine and Barnes-Jewish Hospital recently launched this easy-to-use tool, which offers a wealth of information about risk factors and prevention strategies for five prominent diseases affecting millions of Americans.
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Drink your milk
Dietary calcium is better than supplements at protecting bone health
June 19,
2007 --
Women who get most of their daily calcium from food have healthier bones than women whose calcium comes mainly from supplemental tablets, say researchers at Washington University School of Medicine in St. Louis. Surprisingly, this is true even though the supplement takers have higher average calcium intake. More...
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Men need female hormone, too
Estrogen is important for bone health in men as well as women
May 7,
2007 --
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| DXA scans of a male patient with osteoporosis |
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Although women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating - or even life-threatening - fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at Washington University School of Medicine in St. Louis has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.
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Women volunteers needed
Study to investigate gene's effect on bone loss in breast cancer patients
May 7,
2007 -- Women with estrogen-responsive breast cancer are often prescribed a drug that reduces their estrogen levels. But because estrogen is important to bone health, there is widespread concern about how the estrogen-reducing drugs - called aromatase inhibitors - affect bones. A study at the School of Medicine will investigate bone loss in women taking aromatase inhibitors, and researchers are calling for interested women to volunteer.
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A proactive approach to bone care
A proactive approach to bone care
March 5,
2007 --
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| Photo by Robert Boston |
| Diemer discusses patient Christine Filcoff's treatment after a bone density test. |
Four years ago, Kathryn Diemer was riding her Irish thoroughbred horse, Patronus, when he suddenly bolted. Diemer fell and broke her back. As a physician, she always had felt empathy toward her patients with osteoporosis, a disease that breaks down tissue in bones. But her fall only heightened her sense of sympathy. Compassion, contagious enthusiasm and training at Washington University with top bone clinicians helped Diemer become a leader in her field.
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Keeping bones healthy
Researchers urge monitoring of bone health during chemotherapy
Jan. 11,
2007 --
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| The growth factor G-CSF caused bone tumors to increase in size in lab mice. The mouse on the left did not receive G-CSF. The mouse on the right did. |
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In laboratory tests on mice, researchers found that a medication often used to reduce toxic side effects of chemotherapy induced bone loss and helped tumors grow in bone. So the researchers are recommending increased awareness of bone health during cancer treatments. The medication studied is a growth factor commonly used to help cancer patients recover healthy blood counts after chemotherapy, which can destroy white blood cells.
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Scientific sleuth
Whyte helps solve genetic mystery
Feb. 9,
2006 -- An international team of researchers that includes scientists from Washington University and Shriners Hospital partially untangled the genetic details of a mysterious disorder that formerly caused seizures and death in infant boys within a month of birth. This New York Times article recounts the decades-long quest to identify and understand the causes of the disorder.
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