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Gastroenterology
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From bench to bedside
Heuckeroth receives Clinical Scientist Award in Translational Research
June 5,
2009 --
Robert Heuckeroth has won a Clinical Scientist Award in Translational Research from the Burroughs Wellcome Fund. Heuckeroth, a Washington University pediatric gastroenterologist who treats children with Hirschsprung disease and other gastrointestinal disorders at St. Louis Children's Hospital, was one of only four physician-scientists nationwide to receive the prestigious award.
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Scoping out cancer-causing disorder
Technique eradicates problems in most patients with Barrett's esophagus
May 27,
2009 --
A procedure that uses heat generated by radio waves to treat Barrett's esophagus, a condition caused by acid reflux (severe heartburn), can eliminate signs of the potentially cancer-causing disorder and reduce the risk that the disease will progress.
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Preventing obesity, but not gallstones
Genetically engineered mice don't get obese, but do develop gallstones
May 6,
2009 --
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| Mice lacking the L-Fabp gene (left) don't become obese on a high-fat diet like normal mice. |
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Obesity and gallstones often go hand in hand. But not in mice developed at the School of Medicine. Even when these mice eat high-fat diets, they don't get fat, but they do develop gallstones. Researchers say the findings offer clues about genetic factors related to gallstones, and they believe better understanding of those factors may one day allow physicians to monitor people at risk and even, perhaps, to intervene before gallstones become a serious problem.
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Finding the roots of starvation
$5.5 million from Gates Foundation funds major study of childhood malnutrition
March 31,
2009 -- Scientists who first established a link between obesity and the trillions of friendly microbes that live in the intestine now are investigating whether the organisms can contribute to the converse: severe malnutrition. Researchers at the School of Medicine, led by microbiologist Jeffrey Gordon, M.D., will study whether severely malnourished infants living in Malawi and Bangladesh have a different mix of intestinal microbes than healthy infants in the same areas, and whether those microbes might account for their illness. This three-year, $5.5 million project is funded by the Bill & Melinda Gates Foundation.
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Vitamin A plays key role in regulating bowels
Vitamin A deficiency influences nerve development in the bowel
Nov. 14,
2008 -- In their efforts to understand the cells involved in normal bowel function, researchers at the School of Medicine have found that a common nutrient — Vitamin A, or its metabolite, retinoic acid — has a direct effect on the development of nerve cells, or neurons, in the bowel wall that control gastrointestinal function.
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Smaller stomach leads to big-time weight loss
'Couch potato' peels away weight
Aug. 21,
2008 --
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| By Sarah Conard, St. Louis Post-Dispatch |
| Maria Littrell works out. |
A few days after gastric bypass surgery, Maria Littrell found herself in the grocery, choosing which type of baby food to buy — for herself. Before the operation, Littrell honored her Sicilian heritage by eating pasta — a lot of it, and often. After struggling with her weight for 20 years, Littrell had gastric bypass surgery in September. The surgery reduces the size of the stomach and allows food to bypass part of the small intestine.
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Non-surgical stomach reduction for obesity
First U.S. incision-free procedure for obesity performed at Washington University
July 24,
2008 --
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| Photo by Tim Parker |
| Sreenivasa Jonnalagadda, M.D., and J. Christopher Eagon, M.D., performing the first TOGA procedure in the United States. |
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Doctors at the School of Medicine have performed the first non-surgical procedure in the United States that restricts the size of the stomach to treat obesity. The investigational procedure was performed under direct endoscopic visualization with specialized instruments passed into the stomach through the mouth. The first U.S. patient received the treatment on July 23 at Barnes-Jewish Hospital in St. Louis.
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Named professorship
Stenson named Costrini Professor
Oct. 9,
2007 -- William F. Stenson, M.D., has been named the Dr. Nicholas V. Costrini Professor of Gastroenterology & Inflammatory Bowel Disease at the School of Medicine. Washington University Chancellor Mark S. Wrighton made the announcement with Larry J. Shapiro, M.D., executive vice chancellor for medical affairs and dean of the School of Medicine.
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Toxic tummy
Belly fat may drive inflammatory processes associated with disease
March 8,
2007 --
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| An abdominal MRI scan showing the locations of subcutaneous and visceral fat |
As scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from Washington University School of Medicine in St. Louis suggests that fat in the belly may be an important promoter of that inflammation. It's well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It's the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation. More...
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Multitasking
A three-tiered career: doctor, scientist, professor
Feb. 28,
2007 --
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| Photo by Robert Boston |
| Robert Rothbaum (left) with patient Jordan Allard |
They simply call him "Dr. Bob." Referring to him in a more familiar style is a testament to how comfortable Robert Rothbaum makes his patients feel. The same demeanor also makes him popular with first-year medical students who are adjusting to their new setting. Rothbaum divides his 25-year tenure at the School of Medicine into three "careers." His first career focused on cystic fibrosis, and his second career centered on gastroenterological disorders. His third — and current — career is teaching medical students.
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