Endocrinology, Metabolism & Lipids

Physicians in the Division of Endocrinology, Diabetes and Metabolism diagnose and treat patients with endocrine and metabolic disorders such as thyroid diseases, diabetes, hyperlipidemia and osteoporosis. The division offers patients the very latest in diagnostic and treatment options.

Through research, our physicians also play a leading role in improving patient care. They conduct clinical studies to evaluate the latest treatments and diagnostic procedures, and perform basic science research to pave the way for new advances.

In addition, the division provides an excellent training ground for some of the nation's best medical students, resident physicians and postdoctoral fellows. The division operates one of the nation's top 10 training programs for this subspecialty.

News Stories & Tip Sheets:

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Problem cells Suspected cause of type 1 diabetes caught "red-handed" for the first time May 8, 2008 -- Scientists at the School of Medicine working with diabetic mice have examined in unprecedented detail the immune cells long thought to be responsible for type 1 diabetes. Researchers were able to examine the immune cells from isolated insulin-making structures in the pancreas known as the islets of Langerhans.

Diabetes drugs for depression? Scientists evaluate diabetes drug to treat depression Jan. 31, 2008 -- Scientists at the School of Medicine are seeking individuals who have depression and are overweight to volunteer for a study evaluating whether a diabetes drug might help improve mood. The five-year, NIH-funded study seeks 200 people with depression who are overweight and at risk for developing diabetes.

Quality of life Activating protein enhances average lifespan, limits age-related disease in mice Dec. 4, 2007 -- Metabolism researchers at the School of Medicine have found that although it does not extend maximum lifespan in mice, activating a protein in muscle tissue increases average lifespan and prevents some age-related diseases. The researchers believe a similar approach may someday help people avoid age-related problems such as atherosclerosis, diabetes, hypertension and even some cancers.

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Faculty Experts:

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Philip Cryer Irene E. and Michael M. Karl Professor of Endocrinology and Metabolism The Karl Professor of Endocrinology and Metabolsim, Cryer is a world-renowned expert on diabetes complications and treatment, particularly the problems caused by low blood sugar (hypoglycemia), a common side effect of insulin therapy. Expertise: Diabetes/hypoglycemia and other complications Media assistance: (314) 286-0110 / jdryden@wustl.edu

Jeffrey Moley Director, Translational and Clinical Investigation, Siteman Cancer Center Moley is chief of endocrine and oncologic surgery at the School of Medicine and associate chief of surgery at the St. Louis Veteran's Administration Hospital. He is a world authority on endocrine surgery and endocrine cancers. Moley is especially known for his work on a hereditary cancer known as multiple ... Expertise: Thyroid cancer, endocrine surgery, surgical oncology, musculoskeletal oncology, melanoma Media assistance: (314) 286-0141 / ericsong@wustl.edu

Clay F. Semenkovich Professor of Medicine and Professor of Cell Biology and Physiology Semenkovich Semenkovich is known for his research on lipid metabolism, obesity and atherosclerosis. Expertise: obesity, diabetes, lipid disorders, atheroscilerosis, lipid metaboism Media assistance: (314) 286-0110 / jdryden@wustl.edu

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Related News Clips:

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Kidney ills linked to metabolic syndrome United Press International March 12, 2007 -- A WUSTL study of kidney dialysis patients found nearly 70 percent had metabolic syndrome, considered a predictor of cardiovascular disease. Study leader and WUSTL postdoctoral fellow Daniel Young comments. The study was published in Hemodialysis International.

Cutting Cholesterol By Eating a Cookie The Wall Street Journal Jan. 25, 2007 -- Can a chocolate-chip cookie lower cholesterol? In a junk-food addict's possible dream come true, a number of companies are selling processed foods that aim to lower cholesterol. WUSTL endocrinology and metabolism researcher Anne Goldberg says the evidence is convincing that the products can have a moderate effect on cholesterol, but you must constantly consider calories.

Experimental drug cuts rare, lethal cholesterol levels in patients USA Today Jan. 11, 2007 -- A small study on an experimantal drug released today may have a big effect on people with so much cholesterol in their blood that they can die of heart attacks in their teens and early 20s. WUSTL metabolism researcher Anne Goldberg, who was not involved in the study, comments.

Pediatricians' Weight Could Be Obstacle Associated Press and 102 others Aug. 16, 2005 -- Article on two studies surveying pediatricians and their effectiveness in treating overweight children. Many doctors find obesity difficult to treat because it is a complicated problem. The doctor's own weight could affect his comfort level in counseling an overweight child. WUSTL pediatric endocrinologist Neil White comments.

Gene may increase risk for type 2 diabetes Newsday and 15 others April 26, 2004 -- Two international research teams have uncovered genetic variations that predispose people to develop type 2 diabetes. The School of Medicine team, led by Alan Permutt, professor of medicine at the School of Medicine, studied Ashkenazi Jews from Israel. A team from the National Institutes of Health examined the genetic roots of the disease in people from Finland. Both groups came up with the same results. The researchers discovered that type 2 diabetics are more likely than nondiabetics to inherit a group of common genetic variations in the control region of the hepatocyte nuclear factor 4 alpha gene. The gene encodes a protein that regulates production of hundreds of other proteins important for the development and function of the liver and pancreas.