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Endocrinology, Metabolism & Lipids
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Reducing diabetes risk
Lifestyle changes, drug lower type 2 diabetes risk
Oct. 28,
2009 -- Intensive lifestyle changes aimed at modest weight loss reduced the rate of developing type 2 diabetes by 34 percent over 10 years in people at high risk for the disease, researchers at the School of Medcine report online in The Lancet.
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Preventing diabetes complications
Scientists identify roots of diabetic tissue damage
Oct. 21,
2009 -- Results from comprehensive assessments of diabetes' effects on cell metabolism may aid efforts to reduce diabetic damage to nerves, blood vessels and other tissues, according to researchers at the School of Medicine and elsewhere.
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The skinny on fat
Fat in the liver -- not the belly -- is a better marker for disease risk
Aug. 24,
2009 -- New findings from nutrition researchers at the School of Medicine suggest that it's not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver. They report online in the journal PNAS Early Edition that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body's ability to metabolize sugar.
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Diabetics need D -- the vitamin
Research shows why low vitamin D raises heart disease risks in diabetics
Aug. 21,
2009 -- Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and now researchers at the School of Medicine think they know why. They have found that diabetics deficient in vitamin D can't process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke.
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Food therapy
Food additive may one day help control blood lipids and reduce disease risk
July 30,
2009 -- Scientists at the School of Medicine have identified a substance in the liver that helps process fat and glucose. That substance is a component of the common food additive lecithin, and researchers speculate it may one day be possible to use lecithin products to control blood lipids and reduce risk for diabetes, hypertension or cardiovascular disease using treatments delivered in food rather than medication.
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Moderation may be key for some diabetes drugs
Moderate use averts failure of type 2 diabetes drugs in animal model
Oct. 27,
2008 -- Drugs widely used to treat type 2 diabetes may be more likely to keep working if they are used in moderation, researchers at the School of Medicine have found in a study using an animal model. The drugs, sulfonylureas, help type 2 diabetics make more insulin, improving control of blood sugar levels. But in most patients the effects of sulfonylureas are lost after several years of use, causing insulin secretion to shut down.
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New technique helps lower bad cholesterol
Treatment filters bad cholesterol out of blood
Oct. 9,
2008 -- Diet and lifestyle changes, combined with medication, can lower the risk of heart attack and stroke in patients with high levels of so-called bad cholesterol. But some patients genetically predisposed to high levels of LDL (low-density lipoprotein) don't respond well to drug therapy. Now physicians at the School of Medicine can help these patients with a technique called LDL aphersis.
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Disease and DNA
Gene variants linked to metabolic syndrome and HDL cholesterol levels
June 17,
2008 -- Nutrition researchers at the School of Medicine have identified five common genetic variations that increase the risk of metabolic syndrome, a group of factors linked to heart disease and diabetes. Another variant they found appeared to protect against the condition.
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Problem cells
Suspected cause of type 1 diabetes caught "red-handed" for the first time
May 8,
2008 -- Scientists at the School of Medicine working with diabetic mice have examined in unprecedented detail the immune cells long thought to be responsible for type 1 diabetes. Researchers were able to examine the immune cells from isolated insulin-making structures in the pancreas known as the islets of Langerhans.
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Furthering diabetic research
Schaffer named Minnich professor
Feb. 26,
2008 -- Jean Schaffer has been named the Virginia Minnich Distinguished Professor in Medicine at the School of Medicine. Chancellor Mark S. Wrighton made the announcement with Larry Shapiro, executive vice chancellor for medical affairs and dean of the School of Medicine.
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