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Hematology

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Nutrients help reduce risk of birth defects
 Some neural tube defects in mice linked to enzyme deficiency

May 25,
2009 -- Women of childbearing age can reduce the risk of having a child born with a neural tube defect such as spina bifida by eating enough folate or folic acid. However, folate prevents only about 70 percent of these defects. New research using mice at the School of Medicine confirms the importance of another nutrient, inositol, to protect against the development of neural tube defects.

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Blood donation awareness
 Church effort sharply increases first-time African-American blood donors

Dec. 15,
2008 -- A program at the School of Medicine and St. Louis Children's Hospital designed to increase awareness about sickle cell disease and the importance of blood donations within the African-American faith community led to a 60 percent increase in first-time blood donations, a new study has found.

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Treating sickle cell with stem cells
 Stem cell transplant for sickle cell disease subject of clinical trial

July 11,
2008 -- Children with sickle cell disease often face severe pain, organ damage, recurrent strokes and repeated, prolonged hospital stays. Although there are medical interventions that can lessen the symptoms, there is no cure. Researchers at the School of Medicine are leading a nationwide, multicenter clinical trial to determine the effectiveness of transplanting blood stem cells from unrelated donors into children with severe sickle cell disease.

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New blood
 Blood transfusions help children with sickle cell disease and silent strokes

Dec. 10,
2007 -- A group of children who have sickle cell disease and who experience silent strokes showed some relief from the silent strokes with blood transfusion therapy, researchers at the School of Medicine have found. The study's results will appear in a future issue of Pediatric Blood and Cancer but are available for review in its advance online publication.

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First-of-its-kind procedure
 Bone marrow transplant performed for sickle cell disease

Sept. 25,
2007 -- Bone marrow transplants are best known for their potential to cure people with certain types of cancer. But they also hold promise for people with severe cases of sickle cell anemia, also known as sickle cell disease. Now, in a first-of-its-kind procedure, St. Louis Children's Hospital has performed a bone marrow transplant in a teenager with sickle cell disease, using cells from a donor who is unrelated to him.

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Director named
 Hayashi named director of pediatric hematology/oncology division

May 14,
2007 -- Robert J. Hayashi, M.D., has been named director of the Division of Pediatric Hematology/Oncology in the Department of Pediatrics at Washington University School of Medicine. A member of the faculty at the School of Medicine since 1992, Hayashi is an associate professor of pediatrics.

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Faster healing
 Drug can quickly mobilize an army of cells to repair injury

Sept. 7,
2006 --
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| Red areas of the circled leg in the right image show increased blood flow due to angiogenic cells. |
To speed healing at sites of injury - such as heart muscle after a heart attack or brain tissue after a stroke - doctors would like to be able to hasten the formation of new blood vessels. One promising approach is to "mobilize" patients' blood vessel-forming cells, called angiogenic cells, so these cells can reach the injured area. Recently, researchers at Washington University School of Medicine in St. Louis demonstrated that a drug called AMD3100 can mobilize angiogenic cells from bone marrow of human patients in a matter of hours.

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Consequences of warfarin
 Common blood thinner increases risk of bone fracture

Jan. 23,
2006 -- Elderly patients taking the commonly prescribed blood thinner warfarin experience an increased risk for osteoporosis-linked bone fractures, according to a study at the School of Medicine. The results suggest physicians should carefully monitor the bone health of patients placed on the medication and that their patients should take steps to decrease the risk of osteoporosis.

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Sticking around
 New role for serum amyloid P protein

Oct. 5,
2005 --
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| Photo by David Kilper / WUSTL Photo |
| Scott (left) and Elbert looking for sticky proteins. |
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Biomedical engineers at Washington University in St. Louis have found a new role for the blood protein serum amyloid P in the body's response to medical materials, which may help to explain a variety of problems associated with heart-lung bypass, hemodialysis and the use of artificial vascular grafts. Donald Elbert, Ph.D., Washington University assistant professor of biomedical engineering, used advanced protein separations and mass spectrometry to track the proteins on the surfaces of various polymers used in medical devices. The analysis techniques, collectively called 'proteomics,' are most often used to study protein expression in cells.

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Health concern
 Diabetes Control Week targets poor blood sugar management by St. Louis residents

Sept. 30,
2005 -- More than 70 percent of St. Louis residents with diabetes fail to properly manage their blood sugar, according to the results of a recent study. These results have prompted local lawmakers to declare Oct. 3-7 Diabetes Control Week. Charles Kilo, a diabetes specialist and WUSM professor of clinical medicine, addresses the issue in the following release from PR Newswire.

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