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Anesthesiology

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No lingering effects
 Surgery not linked to memory problems in older patients

Nov. 18,
2009 -- For years, it has been widely assumed that older adults may experience memory loss and other cognitive problems following surgery. But a new study by School of Medicine researchers questions that assumption. In the 575 patients they studied, the investigators did not detect any long-term cognitive declines attributable to surgery.

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Division leader appointed
 Murray named chief of pediatric anesthesiology

Sept. 1,
2009 --
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| Murray |
David J. Murray has been appointed as chief of the Division of Pediatric Anesthesiology at the School of Medicine. Murray, the Carol B. and Jerome T. Loeb Professor and head of medical simulation at the School of Medicine, also becomes anesthesiologist-in-chief at St. Louis Children's Hospital.

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Itching is a pain ? not
 Researchers identify itch-specific neurons in mice, hope for better treatments

Aug. 6,
2009 --
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| Chen |
School of Medicine researchers have discovered that itch-specific neurons exist in mice, and their studies suggest that itch and pain signals are transmitted along different pathways in the spinal cord.

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Scientist recognized
 Crowder named Brown Professor in Anesthesiology

June 16,
2009 -- C. Michael Crowder has been named the Dr. Seymour and Rose T. Brown Professor in Anesthesiology at the School of Medicine. The new appointment was announced by Washington University Chancellor Mark S. Wrighton and by Larry J. Shapiro executive vice chancellor for medical affairs and dean of the School of Medicine.

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Safer use of methadone
 New information points to safer methadone use for treatment of pain and addiction

March 2,
2009 -- New findings may significantly improve the safety of methadone, a drug widely used to treat cancer pain and addiction to heroin and other opioid drugs, according to researchers at the School of Medicine and the University of Washington in Seattle. The researchers discovered that the body processes methadone differently than previously believed.

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Worm's low-oxygen survival skills may aid stroke, heart attack patients
 Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack

Jan. 29,
2009 -- Neurobiologists at the School of Medicine have identified pathways that allow microscopic worms to survive in a low-oxygen, or hypoxic, environment. They believe the finding could have implications for conditions such as stroke, heart attack and cancer. Sensitivity to low oxygen helps determine how damaging those medical conditions can be.

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An itch is not a pain
 Pain and itch responses regulated separately

Nov. 17,
2008 -- Historically, scientists have regarded itching as a less intense version of the body's response to pain, but researchers at the School of Medicine have determined that pain and itch actually are regulated by different molecular mechanisms. Researchers report they have separated itch and pain sensations in mice, a finding that could have important implications for treating both pain and chronic itching.

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Cooled brains may respond better to anesthesia
 Cooling the brain prevents cell death in young mice exposed to anesthesia

Nov. 17,
2008 -- New research from the School of Medicine suggests cooling the brain may prevent the death of nerve cells that has been observed in infant mice exposed to anesthesia. The effects of anesthesia on human infants and young children have been debated among neuroscientists, but growing evidence suggests exposure to anesthetic drugs during brain development may contribute to behavioral and developmental delays.

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Clean slates
 Monitoring device fails to lower risk of anesthesia awareness

March 12,
2008 -- Anesthesiology researchers at the School of Medicine have found that a device used to ensure that surgery patients have no memories of their operations may not lower the risk of the phenomenon known as anesthesia awareness — an extremely rare but distressing occurance.

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Dividing line
 Researchers separate analgesic effects from addictive aspects of pain-killing drugs

Aug. 20,
2007 --
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| Mice developed in the laboratory of Zhou-Feng Chen don't experience relief from pain when given opiate drugs such as morphine. |
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For the first time, pain researchers at the School of Medicine have shown that it's possible to separate the good effects of opiate drugs such as morphine (pain relief) from the unwanted side effects of those drugs (tolerance, abuse and addiction). The investigators, led by Zhou-Feng Chen, Ph.D., associate professor of anesthesiology, psychiatry and molecular biology and pharmacology, report their results online in the Proceedings of the National Academy of Sciences. They found that opiates like morphine don't relieve pain as well in mice genetically engineered to lack neurons that produce a neurotransmitter called serotonin in the central nervous system.

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