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Biochemistry & Molecular Biophysics
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Fixing genetic breaks
New information about DNA repair mechanism could lead to better cancer drugs
July 16,
2009 --
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| Illustration of two proteins involved in DNA repair by artist Amy VanDonsel |
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Researchers at the School of Medicine have shed new light on a process that fixes breaks in the genetic material of cells. The scientists studied protein molecules that have an important role in homologous recombination, which is one way that cells repair breaks in the DNA double helix. Their findings could lead to ways of enhancing chemotherapy drugs that destroy cancer cells by damaging their DNA.
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cWIDR
WUSTL center for study of women's infectious diseases officially opens
May 5,
2008 --
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| Photo courtesy of Scott Hultgren, John Heuser and Robyn Roth |
| A micrograph reveals an E. coli bacterium (in green) that is part of a community of bacteria known as a biofilm. |
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Washington University School of Medicine in St. Louis this week held opening ceremonies for a new center to study infectious diseases that preferentially affect women. The center for Women's Infectious Disease Research (cWIDR) will focus on issues such as microorganisms that cause urinary tract infections (UTIs), infections that lead to premature delivery, and potential contributing roles for microorganisms in life-threatening conditions such as cancer.
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Size matters
Researchers discover pathway to cell size, division
July 30,
2007 -- Researchers at Washington University in St. Louis have discovered through genetic analyses a metabolic pathway in bacteria comprised of just three genes, all known to be players in metabolism. This pathway was previously shown to be involved in synthesizing modified membrane lipids but data from Petra Levin's lab indicate that it also has a major role in cell division. This is the first identification of a pathway responsible for regulating bacterial cell size.
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| Faculty Experts: |
Showing 2 Experts.
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Frank Yin
Chairman of the Department of Biomedical Engineering; The Stephen and Camilla Brauer Distinguished Professor of Biomedical Engineering
Frank C. P. Yin, M.D., Ph.D., the Stephen and Camilla Brauer Professor of Biomedical Engineering and chair of the biomedical engineering department, is a world-renowned biomedical engineer. Yin heads a dynamic, young department, not yet five years old and already ranked among the top 20 in the nation. ...
Expertise: soft tissue mechanics, cell mechanics, hemodynamics
Direct contact: (314) 935-6164
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yin@wustl.edu
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Carl Frieden
The Wittcoff Professor of Biochemistry and Molecular Biophysics
Frieden studies protein folding, protein structure/function relationships, protein-protein interactions and the mechanism of enzymatic reactions. These investigations aim to understand the nature of the intermediate structures on the unfolding and refolding pathways, including the role of proteins ...
Expertise: Biochemistry, molecular biophysics, enzyme, protein folding, chaperones
Media assistance: (314) 286-0141 / ericsong@wustl.edu
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Affiliated with Barnes-Jewish Hospital and St. Louis Children's Hospital, members of BJC HealthCare.
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