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Developmental Biology
Research in the department emphasizes application on the tools of genetics, molecular and cell biology, and bioorganic chemistry to define mechanisms that regulate cell fate, differintiation, and motabablism, and to devise ways of modulating these processes in vivo. A principal focus is on developmental biology using a series of genetically manipulative organisms.
| News Stories & Tip Sheets: |
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New leadership
Solnica-Krezel to lead developmental biology department
Oct. 15,
2009 --
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| Solnica-Krezel |
Lilianna Solnica-Krezel has been named head of the Department of Developmental Biology at the School of Medicine. Larry J. Shapiro, executive vice chancellor for medical affairs and dean of the School of Medicine, announced the appointment, effective Jan.1.
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Red Alert
Skin's defense system may be link between childhood eczema and asthma
Aug. 27,
2009 --
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| Learning the language of cellular signaling: Mitsuru Morimoto, PhD, Shadmehr Demehri, PhD, and Raphael Kopan, PhD. |
Why do children with eczema so often get asthma? Experts in cellular signaling discovered how skin cells in danger might sound a body-wide alert. But lung cells in turn make an unfortunate response.
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The seeds of colon cancer
Scientists identify cells in fruit fly gut that start tumors
Aug. 17,
2009 -- Tumor growth can start from stem cells in the gut, say researchers studying fruit flies at the School of Medicine. They found that tumors can grow from adult stem cells that have lost a specific tumor-suppressor gene. The gene, Apc, has previously been implicated in human gastrointestinal cancers, including colon cancer.
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| Faculty Experts: |
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Michael Welch
Professor of radiology
Welch, an expert in synthetic chemistry, has been a leader for more than 30 years in the development of synthetic imaging agents that have allowed doctors to use positron emission tomography (PET) to diagnose an increasingly wide variety of disorders. He is also head of the Radiochemistry Institute ...
Expertise: PET, nuclear medicine, synthetic chemistry, oncology, imaging agents, radioisotopes, radionuclides
Media assistance: (314) 286-0122 / purdym@wustl.edu
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David Clifford
Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology
Clifford, who is director of the AIDS Clinical Trials Unit (ACTU) at Barnes-Jewish Hospital, is a leading expert on the neurological complications of AIDS and their treatment and management. He has also participated in studies of epilepsy, Parkinson's disease and multiple sclerosis. Clifford is involved ...
Expertise: Neuropharmacology, HIV, AIDS, AIDS-related dementia, peripheral neuropathy, leukoencephalopathy, progressive multifocal leukoencephalopathy, …
Media assistance: (314) 286-0126 / pattoner@wustl.edu
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Frank Yin
Chairman of the Department of Biomedical Engineering; The Stephen and Camilla Brauer Distinguished Professor of Biomedical Engineering
Frank C. P. Yin, M.D., Ph.D., the Stephen and Camilla Brauer Professor of Biomedical Engineering and chair of the biomedical engineering department, is a world-renowned biomedical engineer. Yin heads a dynamic, young department, not yet five years old and already ranked among the top 20 in the nation. ...
Expertise: soft tissue mechanics, cell mechanics, hemodynamics
Direct contact: (314) 935-6164
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yin@wustl.edu
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Jeffrey I. Gordon
The Dr. Robert J. Glaser Distinguished University Professor and Head of the Department of Molecular Biology and Pharmacology and Professor of Medicine
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| Gordon |
Gordon is internationally known for his research on gastrointestinal development and how gut bacteria affect normal intestinal function and predisposition to health and to certain diseases.
Expertise: molecular biology, pharmacology, gut biology, microbes, bacteria, intestines, gastrointestinal development, …
Media assistance: (314) 286-0109 / reckessg@wustl.edu
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David M. Holtzman
Head of the Department of Neurology
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| Holtzman |
Holtzman is known as one of the leading experts in researching the underlying mechanisms that lead to Alzheimer's disease in an effort to improve diagnosis and treatment. In addition to seeing patients at the Alzheimer's Disease Research Center and the Memory Diagnostic Center, Holtzman leads a research ...
Expertise: Alzheimer's disease, dementia, neurology, molecular biology, monoclonal antibodies, amyloid plaques, perinatal stroke
Media assistance: (314) 286-0109 / reckessg@wustl.edu
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Life Without Smell May Not Be Worth It
NPR All Things Considered
Oct. 31,
2008 -- Poet Andrei Codrescu reflects on the implications for humans of a WUSTL medical study on roundworms, which suggests that removing the sense of smell could lead to a longer life.
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Olfactory Hack Tricks Worms Into Living Longer
Wired.com
and 11 others
Oct. 28,
2008 -- WUSTL developmental biologist Kerry Kornfeld comments on new research that suggests the possibility that roundworms who were deprived of their sense of smell lived extra-long.
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Researchers Pinpoint Link Between Caloric Restriction and Longevity
CBC News (Canada)
and 7 others
Sept. 21,
2007 -- Harvard researchers report in the Sept. 21 issue of Cell that they have uncovered a molecular clue that seems to explain why cutting calories might lengthen your life.
It turns out that mitochondria guard against cell death, and two specific genes within the mitochondria actually carry out that task. Mitochondria are compartments within a cell that are dedicated to energy production, and their loss is thought to be a major cause of aging.
WUSTL molecular biology and pharmacology professor Shin-ichiro Imai comments on the Harvard study.
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Blame fat on the bacteria -- again
The Los Angeles Times
and 5 others
Jan. 8,
2007 -- Bacteria in the intestines can modify the body's chemistry to alter the amount of food that becomes stored as fat, according to a finding in mice reported this week that could help in controlling obesity. WUSTL scientist Jeffrey Gordon and his colleagues reported the findings in the current Proceedings of the National Academy of Sciences,
It is unlikely that any manipulation of bacterial levels or composition could produce weight loss, experts said, but drugs that block this activity might.
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Greedy guts?
The Economist (UK)
Jan. 5,
2007 -- Another article on the research led by WUSTL molecular biology and pharmacology professor Jeffrey Gordon that shows the link between a certain kind of gut bacteria and obesity.
Gordon's research is outlined in a paper published in the Proceedings of the National Academy of Sciences and two others published last month in Nature.
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