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New Clues to Sex Anomalies in How Y Chromosomes Are Copied

Article looks at another David Page contribution to the science of genetics.
A weakness in the system that allows the male Y chromosome to protect and repair itself can explain an array of genetic sexual disorders.:
The palindromes were discovered in 2003 when the Y chromosome's sequence of bases, represented by the familiar letters G, C, T and A, was first worked out by David Page of the Whitehead Institute and colleagues at the DNA sequencing center at WUSTL medical school.


References:
  1. Sept. 15, 2009 — New Clues to Sex Anomalies in How Y Chromosomes Are Copied in the The New York Times
Brain Scientists Misled By Squid

Jon Hamilton reports on a recent German study in Science that says that for more than 50 years, scientists who study the brain have been misled by squid. They did experiments on squid nerve cells thinking that those cells were good models for the human nervous system.
WUSTL radiology professor Marcus Raichle, who does brain imaging studies, says, "There is always this tendency that if you're working in an area and your experiments are working well and you're getting good data, to not think of the larger context in which this is occurring."


References:
  1. Sept. 11, 2009 — Brain Scientists Misled By Squid in the NPR Morning Edition
and 1 others.
Commentary: More Funding To End Migraine

Cindy McCain explains the need for more funding for research to cure migraine headaches. As a nation, we spend very little on research into the causes and treatments of migraines. It is estimated that the NIH spends less than $13 million a year for migraine research. Neurology professor Todd Schwedt of WUSTL's Headache Center says that based on the burden migraine exacts from society, funding should be closer to $260 million.


References:
  1. Sept. 9, 2009 — Commentary: More Funding To End Migraine in the Forbes.com
Protein found to control form of diabetes

U. of Iowa scientists say they've discovered a molecular mechanism regulates specialized pancreatic cells and insulin secretion in a form of diabetes. The study that also involved researchers at WUSTL is reported in the early online edition of the Proceedings of the National Academy of Sciences.


References:
  1. Sept. 9, 2009 — Protein found to control form of diabetes in the United Press International
and 4 others.
More Alzheimer genetic risk factors found

An international team of scientists has reported finding two more genetic risk factors of Alzheimer's disease. Includes comments by co-author and WUSTL professor of genetics in psychiatry Alison Goate.


References:
  1. Sept. 8, 2009 — More Alzheimer genetic risk factors found in the United Press International
and 3 others.
Let Orthopedic Surgery Wait Until Morning When Possible

Scheduling a prime daytime slot to undergo an orthopedic procedure may lower your risk of an unplanned follow-up surgery later on, a new study published in The Journal of Bone and Joint Surgery has found.
Includes comments by surgeon William Ricci, chief of WUSTL medical school's Orthopaedic Trauma Service.


References:
  1. Sept. 7, 2009 — Let Orthopedic Surgery Wait Until Morning When Possible in the U.S. News & World Report online
and 8 others.
Pancreatic Cancer Deaths Higher for Blacks

Even after eliminating known pancreatic cancer risk factors, such as smoking and obesity, blacks still had a 42 percent higher risk of dying from the disease than their white counterparts, according to a WUSTL-led study, which appears online in Cancer Epidemiology, Biomarkers & Prevention.


References:
  1. Sept. 2, 2009 — Pancreatic Cancer Deaths Higher for Blacks in the U.S. News & World Report online
and 9 others.
After-hours bone surgery slightly riskier

A study published in the Journal of Bone and Joint Surgery found after-hours orthopaedic surgeries risk a slightly higher rate of necessary follow-up surgeries. WUSTL orthopaedic surgron and lead author William Ricci comments.


References:
  1. Sept. 2, 2009 — After-hours bone surgery slightly riskier in the United Press International
and 3 others.
Girls Gotta Move

In the last decade, there's been a boom in children running races that were once strictly for adults. Getting kids outside and active is obviously a good thing. But are the physical and mental demands of long-distance running safe for children? At what age is competition appropriate, and what do parents need to keep in mind? WUSTL pediatric sports medicine specialist Mark Halstead, who has been a distance runner for most of his adult life, offers advice.


References:
  1. Aug. 30, 2009 — Girls Gotta Move in the Health.com
Belly fat may be innocent bystander

Belly fat has long been blamed for obesity-related disease but it may actually only be something of an innocent bystander, according to research published in the Proceedings of the National Academy of Sciences. Liver fat may be the important risk factor for obesity-related metabolic disorders often linked to diabetes, heart disease and other diseases. Includes comments by senior investigator and WUSTL nutrition expert Samuel Klein.


References:
  1. Aug. 26, 2009 — Belly fat may be innocent bystander in the United Press International
and 2 others.
Child athlete's death revives heart testing debate

An obese eighth-grader's sudden death during a football conditioning lap has revived discussion about whether testing children's hearts before they engage in sports or strenuous activity is necessary. WUSTL cardiovascular professor Keith Mankowitz, who directs an athletes screening program, said some conditions go undetected during routine screening.


References:
  1. Aug. 24, 2009 — Child athlete's death revives heart testing debate in the Associated Press
and 24 others.
Take charge of your checkup

Medical tests are no fun, so why take them twice? People often end up with inadvertently skewed results, but some simple prep work will ensure that your numbers are accurate. Includes advice from WUSTL researchers on how not to skew the PSA (prostate cancer screening) exam.


References:
  1. Aug. 23, 2009 — Take charge of your checkup in the MSNBC.com
Surgeon accused of faking study resigns

Timothy Kuklo, a former U.S. Army surgeon, "voluntarily" resigned from WUSTL, effective Sept. 30, and "will have no clinical, research or educational duties for the university between now and that date," a spokeswoman for the university's medical school said in a statement.


References:
  1. Aug. 20, 2009 — Surgeon accused of faking study resigns in the United Press International
and 1 others.
Surgeon Tied to Bone Product Inquiry Resigns

Timothy Kuklo, a former Army surgeon accused of falsifying a study on a bone growth product used on severely injured Iraq war veterans, has resigned his teaching position at WUSTL, according to spokeswoman Joni Westerhouse.
Kuklo tendered his resignation on July 30, according to Don Clayton, associate vice chancellor and director for medical public affairs. University officials declined to comment further.


References:
  1. Aug. 19, 2009 — Surgeon Tied to Bone Product Inquiry Resigns in the The New York Times
Ultra-tiny 'bees' target tumors

Another report on the use of nanobees -- tiny particles designed to destroy cancer cells by delivering a synthesized version of toxin called melittin that is found in bees.
Samuel Wickline, director of WUSTL's Siteman Center of Cancer Nanotechnology Excellence, explains how it works.
Nanobees are one of the latest examples of how nanotechnology may change the way diseases are treated.


References:
  1. Aug. 18, 2009 — Ultra-tiny 'bees' target tumors in the CNN International
and 1 others.
What's Wrong With This Picture? Baby Is in Danger

"There are a lot of mixed messages that are being sent to families," says pediatrician Rachel Moon, who has probed several widely read parenting and women's magazines and found that many photos in articles and advertisements clash with what the American Academy of Pediatrics recommends parents do to keep infants safe while asleep.
WUSTL pediatrics professor Bradley Thach comments.


References:
  1. Aug. 17, 2009 — What's Wrong With This Picture? Baby Is in Danger in the U.S. News & World Report online
Medical Imaging Under The Gun In Health-Reform Push

Health-reform moves proposed by the White House and pursued in Congress have largely steered clear of direct hits to the medical-technology sector, with one big exception: medical imaging.
Such proposals follow years of rapid growth for medical scanning that has provoked questions about overuse.
William Peck, who directs WUSTL's Center for Health Policy, suggests the House legislation needs to get at the causes of overuse, such as doctors hedging against the threat of malpractice suits.


References:
  1. Aug. 14, 2009 — Medical Imaging Under The Gun In Health-Reform Push in the The Wall Street Journal
and 5 others.
Scientists Identify 'Itchy' Neurons In Mice

Scientists know surprisingly little about the common sensation of itching. But in a recent study of mice, researchers identified specific nerve cells that pass along an itch signal to the brain. And these cells appear to be independent of the pathway for pain. WUSTL anesthesiology professor and co-author Zhou-Feng Chen comments on the study that was published in Science Express.


References:
  1. Aug. 6, 2009 — Scientists Identify 'Itchy' Neurons In Mice in the NPR.org
Genome of Leukemia Patient Reveals Common Mutations

Decoding the genome of a man with acute myeloid leukemia revealed genetic mutations that may be common among other cancer patients. The findings could help scientists understand the genetic basis of cancer. Includes comments by WUSTL researchers Richard Wilson, co-author and director of the Genome Center, and Timothy Ley, study senior author and medicine professor.


References:
  1. Aug. 5, 2009 — Genome of Leukemia Patient Reveals Common Mutations in the U.S. News & World Report online
and 13 others.
Can Toddlers Get Depressed? Yes, and Parents Can Help Them Feel Better

A child psychologist at Montefiore Medical Center in New York, treats tiny babies who have "flat affect" -- no joy in the things that a baby would normally delight in. Refrence made to a WUSTL study on childhood depression [led by WUSTL psychiatry professor Joan Luby].


References:
  1. Aug. 4, 2009 — Can Toddlers Get Depressed? Yes, and Parents Can Help Them Feel Better in the U.S. News & World Report online

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Saturday, Feb. 25, 2006


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