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Scienctists' network
Stimulus grant establishes 'Facebook for scientists'
Nov. 4,
2009 -- The School of Medicine will be one of seven institutions creating a new national network for sharing information between scientists. A $12.2 million grant from National Center for Research Resources (NCRR) will establish the network, which has been described as "Facebook for scientists."
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Preventing diabetes complications
Scientists identify roots of diabetic tissue damage
Oct. 21,
2009 -- Results from comprehensive assessments of diabetes' effects on cell metabolism may aid efforts to reduce diabetic damage to nerves, blood vessels and other tissues, according to researchers at the School of Medicine and elsewhere.
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Appointment announced
Sleckman named Conan Professor of Laboratory and Genomic Medicine
Aug. 11,
2009 --
Barry P. Sleckman has been named the Conan Professor of Laboratory and Genomic Medicine at the School of Medicine. Washington University Chancellor Mark S. Wrighton and Larry Shapiro executive vice chancellor for medical affairs and dean of the School of Medicine, announced the appointment.
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Immune cell self-destruction
Gene regulates immune cells' ability to harm the body
July 16,
2009 -- A recently identified gene allows immune cells to start the self-destructive processes thought to underlie autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis, researchers at the School of Medicine have found.
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Distinguished Pathologist Award
Dehner receives pathologists' highest honor
March 26,
2009 --
Louis P. "Pepper" Dehner, a faculty member at the School of Medicine, received the Distinguished Pathologist Award of the United States and Canadian Academy of Pathology (USCAP) at the academy's 2009 annual meeting. Held in Boston March 7-13, the meeting is the largest annual gathering of pathologists, and the Distinguished Pathologist Award is its highest honor.
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Brain builder
Well-known enzyme is unexpected contributor to brain growth
March 11,
2009 -- An enzyme researchers have studied for years because of its potential connections to cancer, diabetes, heart disease, hypertension and stroke appears to have yet another major role to play: helping create and maintain the brain. When scientists at the School of Medicine selectively disabled the enzyme AMP-activated protein kinase (AMPK) in mouse embryos, overall brain size was reduced by 50 percent, the cerebrum and cerebellum were shrunken, and the mice died within three weeks of birth.
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Genetic data helps determine dosage
Genetic information can improve administration of anticoagulant
Feb. 18,
2009 -- Each year in the United States, doctors start about 2 million patients on warfarin (Coumadin™), an anticoagulant drug that's notoriously hard to administer. Now a study from the International Warfarin Pharmacogenetics Consortium (IWPC), which includes researchers from the School of Medicine, confirms that using a patient's genetic information can make it easier to get the warfarin dose right.
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Rare anti-inflammatory agents discovered
Previously unknown immune cell may help those with Crohn's and colitis
Nov. 3,
2008 -- The tonsils and lymphoid tissues in the intestinal tract that help protect the body from external pathogens are the home base of a rare immune cell newly identified by researchers at the School of Medicine. The researchers indicate that the immune cells could have a therapeutic role in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis.
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Cells damage their own DNA to activate genes
Seemingly suicidal stunt is normal rite of passage for immune cells
Oct. 20,
2008 -- Researchers have shown that self-induced breaks in the DNA of immune cells known as lymphocytes activate genes that cause the cells to travel from where they're made to where they help the body fight invaders. The new finding is the first to link such serious damage to activation of genes not directly involved in the cells' attempts to either fix the harm or self-destruct to stop themselves from becoming cancerous.
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Immune cell link intrigues Crohn's disease researchers
Form of Crohn's disease traced to disabled gut cells
Oct. 5,
2008 -- Scientists report in this week's Nature that they have linked the health of specialized gut immune cells to a gene associated with Crohn's disease, an often debilitating and increasingly prevalent inflammatory bowel disorder. The link to immune cells intrigued researchers at the School of Medicine because they and others believe Crohn's disease is caused by misdirected immune responses in the intestine that damage gut tissue.
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