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URL: http://mednews.wustl.edu/group/page/normal/204.html

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News Stories & Tip Sheets:

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Brain injury and Alzheimer's disease

Rapid changes in key Alzheimer's protein described in humans (http://mednews.wustl.edu/news/page/normal/12226.html)

Aug. 28, 2008 -- For the first time, researchers have described hour-by-hour changes in the amount of amyloid beta, a protein that is believed to play a key role in Alzheimer's disease, in the human brain. A team of scientists at the School of Medicine and the University of Milan report their results this week in Science.


Surprising details about gene that affects height

Gene's newly explained effect on height may change tumor disorder treatment (http://mednews.wustl.edu/news/page/normal/12134.html)

Aug. 11, 2008 -- A mutation that causes a childhood tumor syndrome also impairs growth hormone secretion, researchers at the School of Medicine have found. The discovery provides new insights into an old mystery, revealing why patients with neurofibromatosis type 1 are frequently shorter than their peers. The surprising details have led scientists to consider modifying their search for treatments for the inherited disorder, which is caused by a mutation in the neurofibromin 1 (NF1) gene and is characterized by an increased risk of cancer.


Brain tweak lets sleep-deprived flies stay sharp

Brain tweak lets sleep-deprived flies stay sharp (http://mednews.wustl.edu/news/page/normal/12092.html)

July 31, 2008 --
Scientists testing sleep's effects on learning have devised a model that presents fruit flies with a simple choice: fly into a lighted vial or a darkened one.
Scientists testing sleep's effects on learning have devised a model that presents fruit flies with a simple choice: fly into a lighted vial or a darkened one.
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Staying awake slows down our brains, scientists have long recognized. Mental performance is at its peak after sleep but inevitably trends downward throughout the day, and sleep deprivation only worsens these effects. For the first time, researchers at the School of Medicine have found a way to stop this downward slide. When scientists genetically tweaked a part of the brain involved in learning and memory in fruit flies, the flies were unimpaired even after being deprived of sleep.



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Faculty Experts:

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Steven Petersen

James S. McDonnell Professor of Cognitive Neuroscience in Neurology (http://mednews.wustl.edu/sb/page/normal/502.html)

Petersen is chief of the Neuropsychology Division and a pioneer in using brain imaging to identify brain regions that contribute to attention, learning, memory and language. He also investigates the effects of disease and brain damage on these cognitive processes, bridging a range of psychological ...


Expertise: Neuroscience, cognitive neuroscience, neuropyschology, brain imaging, functional magnetic resonance imaging (fMRI), positron emission tomography (PET), attention, …

Media assistance: (314) 286-0122 / purdym@wustl.edu


David Clifford

Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology (http://mednews.wustl.edu/sb/page/normal/704.html)

Clifford, who is director of the AIDS Clinical Trials Unit (ACTU) at Barnes-Jewish Hospital, is a leading expert on the neurological complications of AIDS and their treatment and management. He has also participated in studies of epilepsy, Parkinson's disease and multiple sclerosis. Clifford is involved ...


Expertise: Neuropharmacology, HIV, AIDS, AIDS-related dementia, peripheral neuropathy, leukoencephalopathy, progressive multifocal leukoencephalopathy, …

Media assistance: (314) 286-0126 / pattoner@wustl.edu


David Gutmann, M.D., Ph.D.

Donald O. Schnuck Family Professor of Neurology (http://mednews.wustl.edu/sb/page/normal/586.html)

Gutmann is the founder and director of the Neurofibromatosis Clinical Program, which is dedicated to treating the common inherited tumor predisposition syndrome, neurofibromatosis (NF). Individuals with NF have an increased risk of developing brain tumors and other cancers. As national leader in the ...


Expertise: Brain tumors, cancer genetics, neurofibromatosis, molecular genetics, neurosciences, neurology

Media assistance: (314) 286-0122 / purdym@wustl.edu


David Carr

Associate Professor of Medicine and Neurology (http://mednews.wustl.edu/sb/page/normal/608.html)

Carr
Carr

Carr's interests are in caring for older adults in outpatient and long-term care settings. His current projects include research on the safety of older drivers, and evaluating the efficacy of units dedicated to oncology acute care and cardiology acute care for the elderly. Carr is the clinical director ...


Expertise: geriatrics, nutritional science, memory, aging

Media assistance: (314) 286-0109 / reckessg@wustl.edu


John Morris

Director and Principal Investigator, Alzheimer's Disease Research Center, Department of Neurology (http://mednews.wustl.edu/sb/page/normal/503.html)

John Morris
Morris
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John C. Morris, M.D., is the Harvey A. and Dorismae Hacker Friedman Distinguished Professor of Neurology, Professor of Pathology and Immunology and of Physical Therapy, and the Director of the Alzheimer Disease Research Center, Center for Aging, the Memory and Aging Project, and the Memory Diagnostic ...


Expertise: Alzheimer's disease, dementia, memory, aging, mild cognitive impairment

Media assistance: (314) 286-0122 / purdym@wustl.edu



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Related News Clips:

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Show More Clips
Tracking Alzheimer's-linked protein in live brains
Associated Press and 79 others

Aug. 29, 2008 -- Researchers at WUSTL and the University of Milan found that levels of a protein linked with Alzheimer's disease rise as people recover from brain injuries - a surprising finding that may help explain why injuries boost the risk of developing the disease. WUSTL neurology professor David Brody comments.


Neuron Killers
Science News

Aug. 4, 2008 -- The method by which "bad" proteins bump off neurons is also a matter of dispute. Scientists are drawing ever closer to solutions for these mysteries, and what they discover may one day help head off these diseases or even repair some damage after rogue proteins have vandalized the brain or spinal cord.


Scientists Identify the Brain's Activity Hub
The New York Times and 1 others

July 1, 2008 -- The outer layer of the brain, the reasoning, planning and self-aware region known as the cerebral cortex, has a central clearinghouse of activity below the crown of the head that is widely connected to more-specialized regions in a large network similar to a subway map, scientists reported.
"This is just about the coolest paper I've seen in a long time, and forward-looking in terms of where the science is going," said WUSTL neurology and radiology professor Marcus Raichle, who was not involved in the research.


Celebrex, Naproxen Won't Prevent Mental Decline
U.S. News & World Report and 9 others

May 13, 2008 -- Contrary to prior studies, a new trial shows that daily use of two popular pain-relieving drugs, Celebrex and naproxen, does not prevent cognitive decline in people with a family history of Alzheimer's disease. WUSTL neurology professor John Morris, who is director of WUSTL's Alzheimer's Disease Research Center and a member of the medical and scientific advisory council for the Alzheimer's Association, comments.


Study Details New Molecular Approach to Preventing Alzheimer's
The Washington Post and 7 others

April 25, 2008 -- German researchers are reporting a new approach to the possible prevention of the molecular "debris" that's associated with the development of Alzheimer's disease.
WUSTL neurology professor James Galvin called the German research "a novel idea."




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