Media Assistance:
 Jim Dryden Assoc. Dir. of Broadcast Services jdryden@wustl.edu (314) 286-0110 |
Research in the department emphasizes application on the tools of genetics, molecular and cell biology, and bioorganic chemistry to define mechanisms that regulate cell fate, differintiation, and motabablism, and to devise ways of modulating these processes in vivo. A principal focus is on developmental biology using a series of genetically manipulative organisms.
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| Anticancer, anti-heart Certain anticancer agents could be harmful to patients with heart disease (http://mednews.wustl.edu/news/page/normal/11940.html) June 20, 2008 -- A set of promising new anticancer agents could have unforeseen risks in individuals with heart disease, suggests research at the School of Medicine. The anticancer drugs — which go by the strange name of hedgehog antagonists — interfere with a biochemical process that promotes growth in some cancer cells. But the researchers showed that interfering with this biochemical process in mice with heart disease led to further deterioration of cardiac function and ultimately death. |
| Algorithm finds the network - for genes or the Internet Math tool finds genetic communities that lead to disease (http://mednews.wustl.edu/tips/page/normal/11221.html) March 12, 2008 -- Human diseases and social networks seem to have little in common. However, at the crux of these two lies a network, communities within the network, and farther even, substructures of the communities. Weixiong Zhang, Ph.D., Washington University associate professor of computer science and engineering and of genetics, along with his Ph.D. student, Jianhua Ruan, has published an algorithm (a recipe of computer instructions) to automatically discover communities and their subtle structures in various networks. |
| Broad-spectrum antibiotics battle IBD Scientists successfully treat new mouse model of inflammatory bowel disease (http://mednews.wustl.edu/news/page/normal/11240.html) March 5, 2008 -- Researchers trying to improve cancer immune therapy have made an unexpected find: They've produced the most accurate mouse model to date of inflammatory bowel disease (IBD), a cluster of conditions that afflict approximately 1.4 million Americans with abdominal pain, constipation and diarrhea. |
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| Faculty Experts: |
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| Michael Welch Professor of radiology (http://mednews.wustl.edu/sb/page/normal/713.html) Welch, an expert in synthetic chemistry, has been a leader for more than 30 years in the development of synthetic imaging agents that have allowed doctors to use positron emission tomography (PET) to diagnose an increasingly wide variety of disorders. He is also head of the Radiochemistry Institute ... Expertise: PET, nuclear medicine, synthetic chemistry, oncology, imaging agents, radioisotopes, radionuclides Media assistance: (314) 286-0122 / purdym@wustl.edu |
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| David Clifford Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology (http://mednews.wustl.edu/sb/page/normal/704.html) Clifford, who is director of the AIDS Clinical Trials Unit (ACTU) at Barnes-Jewish Hospital, is a leading expert on the neurological complications of AIDS and their treatment and management. He has also participated in studies of epilepsy, Parkinson's disease and multiple sclerosis. Clifford is involved ... Expertise: Neuropharmacology, HIV, AIDS, AIDS-related dementia, peripheral neuropathy, leukoencephalopathy, progressive multifocal leukoencephalopathy, … Media assistance: (314) 286-0126 / pattoner@wustl.edu |
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| Frank Yin Stephen and Camilla Brauer Professor of Biomedical Engineering (http://mednews.wustl.edu/sb/page/normal/349.html)
Frank C. P. Yin, M.D., Ph.D., the Stephen and Camilla Brauer Professor of Biomedical Engineering and chair of the biomedical engineering department, is a world-renowned biomedical engineer. Yin heads a dynamic, young department, not yet five years old and already ranked among the top 20 in the nation. ... Expertise: soft tissue mechanics, cell mechanics, hemodynamics Direct contact: (314) 935-6164 / yin@biomed.wustl.edu |
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| Jeffrey I. Gordon The Dr. Robert J. Glaser Distinguished University Professor and Head of the Department of Molecular Biology and Pharmacology and Professor of Medicine (http://mednews.wustl.edu/sb/page/normal/182.html)
Gordon is internationally known for his research on gastrointestinal development and how gut bacteria affect normal intestinal function and predisposition to health and to certain diseases. Expertise: molecular biology, pharmacology, gut biology, microbes, bacteria, intestines, gastrointestinal development, … Media assistance: (314) 286-0109 / reckessg@wustl.edu |
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| David M. Holtzman Head of the Department of Neurology (http://mednews.wustl.edu/sb/page/normal/178.html)
Holtzman is known as one of the leading experts in researching the underlying mechanisms that lead to Alzheimer's disease in an effort to improve diagnosis and treatment. In addition to seeing patients at the Alzheimer's Disease Research Center and the Memory Diagnostic Center, Holtzman leads a research ... Expertise: Alzheimer's disease, dementia, neurology, molecular biology, monoclonal antibodies, amyloid plaques, perinatal stroke Media assistance: (314) 286-0109 / reckessg@wustl.edu |
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| Researchers Pinpoint Link Between Caloric Restriction and Longevity
CBC News (Canada) and 7 others Sept. 21, 2007 -- Harvard researchers report in the Sept. 21 issue of Cell that they have uncovered a molecular clue that seems to explain why cutting calories might lengthen your life. It turns out that mitochondria guard against cell death, and two specific genes within the mitochondria actually carry out that task. Mitochondria are compartments within a cell that are dedicated to energy production, and their loss is thought to be a major cause of aging. WUSTL molecular biology and pharmacology professor Shin-ichiro Imai comments on the Harvard study. |
| Blame fat on the bacteria -- again
The Los Angeles Times and 5 others Jan. 8, 2007 -- Bacteria in the intestines can modify the body's chemistry to alter the amount of food that becomes stored as fat, according to a finding in mice reported this week that could help in controlling obesity. WUSTL scientist Jeffrey Gordon and his colleagues reported the findings in the current Proceedings of the National Academy of Sciences, It is unlikely that any manipulation of bacterial levels or composition could produce weight loss, experts said, but drugs that block this activity might. |
| Greedy guts?
The Economist (UK) Jan. 5, 2007 -- Another article on the research led by WUSTL molecular biology and pharmacology professor Jeffrey Gordon that shows the link between a certain kind of gut bacteria and obesity. Gordon's research is outlined in a paper published in the Proceedings of the National Academy of Sciences and two others published last month in Nature. |
| Intestinal bacteria may explain obesity
ABC News online and 58 others June 14, 2006 -- The microorganisms that live in your gut could explain one of the sources of obesity, says a new study from researchers at Washington University led by molecular biology and pharmacology professor Jeffrey Gordon and colleague Buck Samuel. Bacteria live throughout the body, but some intestinal bacteria appear to be better than others at helping their hosts turn food into energy. The results of the study are published in the Proceedings of the National Academy of Sciences. |
| Beta-Blocker Drugs May Pose Dangers for Some
Forbes.com and 10 others Sept. 28, 2005 -- Widely used beta-blocker blood pressure medications can raise the risk of death in patients with specific genes who receive the drugs after a heart attack or unstable angina, according to a study led by WUSTL researchers David Lanfear and Howard McLeod. Another study scheduled to begin at WUSTL will look for the appropriate treatments for patients whose genetic makeup might make beta-blocker use hazardous. |
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