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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
Professor of Medicine and Professor of Cell Biology and Physiology
- Professor, Cell Biology & Physiology
- Professor, Medicine
- Director, Division of Endocrinology, Metabolism, & Lipid Research, Endocrinology, Metabolism & Lipids
- Director, Division of Endocrinology, Metabolism, & Lipid Research,
Expertise: obesity, diabetes, lipid disorders, atheroscilerosis, lipid metaboism
Bio:
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| Semenkovich |
Semenkovich is known for his research on lipid metabolism, obesity and atherosclerosis.
Education:
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M.D. at Washington University
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B.A. at University of Virginia
Steve Jobs' Illness Offers Complex Mystery
WUSTL endocrinologist Clay Semenkovich comments on Apple CEO Steve Jobs' cryptic statements regarding his health.
References:
- Jan. 15,
2009
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Steve Jobs' Illness Offers Complex Mystery
in the npr.org
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Apple's Jobs Under Treatment to Gain Weight
WUSTL endocrinologist Clay Semenkovich is one of the specialists asked to comment on the diagnosis of Steve Jobs.
References:
- Jan. 6,
2009
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Apple's Jobs Under Treatment to Gain Weight
in the The Wall Street Journal online
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Decoding The Health Statement Of Apple's Jobs
When Apple CEO Steve Jobs put out a cryptic statement this week about his widely discussed weight loss, he practically guaranteed a new round of speculation about its cause. Includes comments by WUSTL endocrinologist Clay Semenkovich.
References:
- Jan. 6,
2009
—
Decoding The Health Statement Of Apple's Jobs
in the NPR.org
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Endocrinologists Weigh in on Steve Jobs' Hormonal Imbalance
Katy Marquardt blogs about what endocrinologists are saying about the diagnosis of Steve Jobs. Includes comments by WUSTL endocrinology chief Clay Semenkovich.
References:
- Jan. 6,
2009
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Endocrinologists Weigh in on Steve Jobs' Hormonal Imbalance
in the U.S. News & World Report blogs
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Study suggests new factor contributing to heart disease
According to a new WUSTL study published in Nature, faulty metabolism can damage your heart. This new study indicates that bad metabolism could cause blockages in blood vessels, which can lead to heart attacks and strokes. WUSTL cell biologist and physiologist Clay Semenkovich comments.
References:
- May 26,
2005
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Study suggests new factor contributing to heart disease
in the St. Louis Post-Dispatch
and 35 others.
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Need to eat some fat to burn fat
Working with mice, WUSTL researchers led by cell biology and physiology professor Clay Semenkovich found that where fat comes from determines whether the body can metabolize it effectively. Fat around the belly, thighs or bottom can't be burned efficiently unless "new" fat is eaten in the diet or made in the liver.
References:
- May 9,
2005
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Need to eat some fat to burn fat
in the myDNA.com
and 9 others.
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Additional Background: Semenkovich's research focuses on how the body breaks down and uses fats called lipids. In particular, he investigates how this process can promote narrowing and hardening of the arteries -- a disease known as atherosclerosis -- in people with diabetes. Using genetically modified mice, Semenkovich has shown that an enzyme called LPL can promote atherosclerosis and affect insulin secretion. In attempt to combat the heart disease, diabetes and obesity that have been shown to accompany a high-fat diet, Semenkovich has created a strain of mice that produce a protein called uncoupling protein-1 in their skeletal muscles. Production of that protein mimics the effects of exercise in the mice. These mice were able to consume high-fat diets and stay healthy and slim, despite lack of exercise. Semenkovich also uses genetically engineered mice to study the role of metabolism in aging and atherosclerosis.
Affiliated with Barnes-Jewish Hospital and St. Louis Children's Hospital, members of BJC HealthCare.
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