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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
The Dr. Robert J. Glaser Distinguished University Professor and Head of the Department of Molecular Biology and Pharmacology and Professor of Medicine
Expertise: molecular biology, pharmacology, gut biology, microbes, bacteria, intestines, gastrointestinal development, gut microorganisms, bacterial genome sequencing, comparative microbial genomics, microbial ecology, gastrointestinal diseases, gut stem cells, mouse models
Bio:
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| Gordon |
Gordon is internationally known for his research on gastrointestinal development and how gut bacteria affect normal intestinal function and predisposition to health and to certain diseases.
Education:
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M.D. at University of Chicago
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B.A. in Biology at Oberlin College
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Microbial menagerie
Junk food binge alters community of microbes in the gut in less than a day
Nov. 11,
2009 -- Switching from a low-fat, plant-based diet to one high in fat and sugar alters the collection of microbes living in the gut in less than a day, with obesity-linked microbes suddenly thriving, according to new research at the School of Medicine. The study was based on transplants of human intestinal microbes into germ-free mice.
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Finding the roots of starvation
$5.5 million from Gates Foundation funds major study of childhood malnutrition
March 31,
2009 -- Scientists who first established a link between obesity and the trillions of friendly microbes that live in the intestine now are investigating whether the organisms can contribute to the converse: severe malnutrition. Researchers at the School of Medicine, led by microbiologist Jeffrey Gordon, M.D., will study whether severely malnourished infants living in Malawi and Bangladesh have a different mix of intestinal microbes than healthy infants in the same areas, and whether those microbes might account for their illness. This three-year, $5.5 million project is funded by the Bill & Melinda Gates Foundation.
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To each his own bacteria
Research in twins defines shared features of the human gut microbial communities: variations linked to obesity
Dec. 2,
2008 -- Trillions of microbes make their home in the gut, where they help to break down and extract energy and nutrients from the food we eat. Yet, scientists have understood little about how this distinctive mix of microbes varies from one individual to the next. Now, researchers at the School of Medicine have discovered that each individual carries a unique collection of bacteria, although the communities are more similar among family members.
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High honors for WUSM scientists
Gordon, Holtzman elected to Institute of Medicine
Oct. 13,
2008 -- Two faculty members at the School of Medicine have been elected to the Institute of Medicine of the National Academy of Sciences, one of the highest honors medical scientists in the United States can receive. Jeffrey Gordon and David Holtzman were recognized for their major contributions to the advancement of the medical sciences, health care and public health and commitment to service.
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Differences in gut bacteria
'Obese bacteria' harvest calories better, may cause weight gain
Dec. 28,
2006 --
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| Gordon |
The trillions of bacteria living within the human digestive tract have a great effect on an individual's weight. The genetic makeup of that bacteria can determine how well a person breaks down food in the gut. Listen to WUSM scientist Jeffrey Gordon, a leading researcher on gut bacteria and obesity, as he explains in an NPR segment how different types of bacteria can affect a person's weight.
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Obese or lean
Relative abundance of common microbes living in the gut may contribute to obesity
Dec. 20,
2006 -- A link between obesity and the microbial communities living in our guts is suggested by new research at the School of Medicine. The findings indicate that our gut microbes are biomarkers, mediators and potential therapeutic targets in the war against the worldwide obesity epidemic.
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Exploiting tumor vulnerabilities
Unusual three-drug combo inhibits growth of aggressive tumors
Sept. 7,
2006 --
An experimental anti-cancer regimen combined a diuretic, a Parkinson's disease medication and a drug ordinarily used to reverse the effect of sedatives. In research conducted at Washington University School of Medicine in St. Louis, the unusual mixture inhibited the growth of aggressive prostate tumors in laboratory mice.
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Bacteria can make you gain weight
Gut microbes' partnership helps body extract energy from food, store it as fat
June 12,
2006 -- Researchers have found that two common organisms collude and collaborate to increase the amount of calories harvested from a class of carbohydrates found in food sweeteners. In the study, conducted in previously germ-free mice, colonization with two prominent human gut microbes led to fatter mice. Scientists at the School of Medicine called the results an illustration of how understanding the menagerie of microorganisms that live in our guts can provide new insights into health.
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Huge numbers of tiny 'bugs'
World within helps keep people functioning properly
June 7,
2006 -- Humans are more than human, according to a recent study by WUSM researcher Jeffrey Gordon. The trillions of microbes living in the human digestive system not only outnumber actual human cells 10-to-1, but they are also essential to good health.
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Gut bugs
Intestinal microbes studied as cause of obesity
May 22,
2006 -- More than 10 trillion bacteria live inside the human digestive system, and Jeffrey Gordon, director of the Center for Genome Sciences, believes these microbes are a major cause of obesity. Regulating numbers and types of bacteria may someday be an effective treatment for obesity, he says.
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Additional Background: Gordon is known for his research on gastrointestinal development and how bacteria that normally reside inside the human body affect intestinal function. By using germ-free mice colonized with normal gut microbes and tools developed during the current revolution in genomics, Gordon has begun to illuminate the complex interaction between microbes, the lining of the intestine and the immune system. His group also studies the molecular features of gut stem cells, which fuel the perpetual renewal of the interior lining of the gastrointestinal tract. In addition, his group is characterizing the enzyme N-myristoyltransferase (Nmt). Nmt is critical for the function of many proteins involved in cell signaling and growth and is the target for development of new drugs to kill fungal pathogens that infect humans whose immune systems are compromised.
Affiliated with Barnes-Jewish Hospital and St. Louis Children's Hospital, members of BJC HealthCare.
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