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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
Danforth Professor
Expertise: Obesity, nutrition, weight loss
Bio:
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| Klein |
The Danforth Professor of Medicine and Nutritional Sciences, Samuel Klein is an internationally renowned expert on obesity and weight loss.
Education:
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B.S. at Brandeis
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M.D. at Temple
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M.S. in Nutritional biochemistry and metabolism at MIT
| News Stories & Tip Sheets: |
Showing Stories 1 through 5 of 18.
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The skinny on fat
Fat in the liver -- not the belly -- is a better marker for disease risk
Aug. 24,
2009 -- New findings from nutrition researchers at the School of Medicine suggest that it's not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver. They report online in the journal PNAS Early Edition that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body's ability to metabolize sugar.
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Liver fat key to diabetes, heart disease
Apple or pear shape is not main culprit to heart woes — it's liver fat
Dec. 3,
2008 -- Pear-shaped people who carry weight in the thighs and backside have been told for years they are at lower risk for high blood pressure and heart disease than apple-shaped people who carry fat in the abdomen. But in two studies, School of Medicine researchers report that body shape isn't the only marker of risk. Excess liver fat appears to be the key to insulin resistance, cholesterol abnormalities and other problems that contribute to diabetes and cardiovascular disease.
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Toxic tummy
Belly fat may drive inflammatory processes associated with disease
March 8,
2007 --
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| An abdominal MRI scan showing the locations of subcutaneous and visceral fat |
As scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from Washington University School of Medicine in St. Louis suggests that fat in the belly may be an important promoter of that inflammation. It's well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It's the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation. More...
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Under the skin
Hidden abdominal fat may pose greater health risks than visible body fat
May 24,
2006 -- A growing number of Americans are overweight or obese, but where they store those extra pounds may be as important as how many extra pounds they carry. Visceral fat, hidden inside the abdomen, has been linked to higher rates of various metabolic ailments, including diabetes and heart disease.
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Controlling the fat
Researchers study effects of weight loss in adolescents
April 3,
2006 -- A team of researchers at the School of Medicine is studying how fatty liver disease affects sugar and fat metabolism in overweight adolescents and how losing weight affects the condition. In the last 30 years, the number of overweight children has doubled in the United States, and overweight children are at increased risk for the problem.
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Showing Stories 1 through 5 of 18.
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Belly fat may be innocent bystander
United Press International
and 2 others
Aug. 26,
2009 -- Belly fat has long been blamed for obesity-related disease but it may actually only be something of an innocent bystander, according to research published in the Proceedings of the National Academy of Sciences. Liver fat may be the important risk factor for obesity-related metabolic disorders often linked to diabetes, heart disease and other diseases. Includes comments by senior investigator and WUSTL nutrition expert Samuel Klein.
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Fountain Of Youth In A Wine Rx?
CBS 60 Minutes
Jan. 26,
2009 -- Morley Safer meets with members of CRS, the Calorie Restriction Society, a group that's been severely restricting their calories for years now. They are also part of a WUSTL study to see if this kind of self-denial make them live longer, healthier lives.
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Study: When kids become teens, they get sluggish
Associated Press Online
and 79 others
July 16,
2008 -- One of the largest studies of its kind shows just how sluggish American children become once they hit the teen years: While 90 percent of 9-year-olds get a couple of hours of exercise most days, fewer than 3 percent of 15-year-olds do.
WUSTL nutrition expert Samuel Klein, director of WUSTL medical school's Human Nutritioin Center, said the research provides a more powerful snapshot than previous studies.
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Additional Background: Klein, the Danforth Professor of Medicine and Nutritional Sciences, also is director of the Division of Geriatrics and Nutritional Sciences at the School of Medicine. He directs the University's Center for Human Nutrition, and is associate program director of the University's General Clinical Research Center and medical director of both the Washington University Weight Management Center and the Barnes-Jewish Hospital Nutrition Support Service. Klein has developed several new clinical and research programs aimed at prevention and therapy for nutrition-related diseases. Klein has developed several new clinical and research programs aimed at prevention and therapy for nutrition-related diseases. In his role with the Washington University Weight Management Center, Klein helps provide patients with long-term therapy for obesity. Current clinical research includes assessment of diet comosition on weight loss and the regulation of fat metabolism in obesity.
Affiliated with Barnes-Jewish Hospital and St. Louis Children's Hospital, members of BJC HealthCare.
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