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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
Danforth Professor
Expertise: Obesity, nutrition, weight loss
Bio:
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| Klein |
The Danforth Professor of Medicine and Nutritional Sciences, Samuel Klein is an internationally renowned expert on obesity and weight loss.
Education:
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B.S. at Brandeis
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M.D. at Temple
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M.S. in Nutritional biochemistry and metabolism at MIT
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The skinny on fat
Fat in the liver -- not the belly -- is a better marker for disease risk
Aug. 24,
2009 -- New findings from nutrition researchers at the School of Medicine suggest that it's not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver. They report online in the journal PNAS Early Edition that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body's ability to metabolize sugar.
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Liver fat key to diabetes, heart disease
Apple or pear shape is not main culprit to heart woes — it's liver fat
Dec. 3,
2008 -- Pear-shaped people who carry weight in the thighs and backside have been told for years they are at lower risk for high blood pressure and heart disease than apple-shaped people who carry fat in the abdomen. But in two studies, School of Medicine researchers report that body shape isn't the only marker of risk. Excess liver fat appears to be the key to insulin resistance, cholesterol abnormalities and other problems that contribute to diabetes and cardiovascular disease.
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Toxic tummy
Belly fat may drive inflammatory processes associated with disease
March 8,
2007 --
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| An abdominal MRI scan showing the locations of subcutaneous and visceral fat |
As scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from Washington University School of Medicine in St. Louis suggests that fat in the belly may be an important promoter of that inflammation. It's well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It's the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation. More...
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Under the skin
Hidden abdominal fat may pose greater health risks than visible body fat
May 24,
2006 -- A growing number of Americans are overweight or obese, but where they store those extra pounds may be as important as how many extra pounds they carry. Visceral fat, hidden inside the abdomen, has been linked to higher rates of various metabolic ailments, including diabetes and heart disease.
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Controlling the fat
Researchers study effects of weight loss in adolescents
April 3,
2006 -- A team of researchers at the School of Medicine is studying how fatty liver disease affects sugar and fat metabolism in overweight adolescents and how losing weight affects the condition. In the last 30 years, the number of overweight children has doubled in the United States, and overweight children are at increased risk for the problem.
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Fighting fat
Weighing answers to obesity
Jan. 26,
2006 --
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| Klein |
Humans are genetically programmed to eat food and store energy as fat. Americans today have a variety of energy-saving devices at their disposal, which actually makes it hard for them to burn off that stored energy, says Samuel Klein, director of the Center for Human Nutrition. Klein and his colleagues are dedicated to improving health and preventing obesity using pioneering research, community programs and nutrition education.
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'Tis the season
Preventing holiday weight gain is easier than losing extra pounds
Nov. 17,
2005 --
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| Holiday food can add unwanted pounds. |
January is no stranger to extra pounds. As long as Americans have celebrated their fall and winter holidays, many have entered the new year carrying a little extra baggage. With weight becoming an ever-growing concern in the U.S., WUSM nutrition expert Samuel Klein discusses ways to avoid extra holiday pounds in the following Newsweek column.
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Hormonal imbalance
Recognizing the signs of Polycystic Ovarian Syndrome
Sept. 7,
2005 -- Bodies change a lot during puberty, and it's not uncommon for young female teens to experience irregular initial menstrual periods. Parents, however, need to be watchful if their daughters begin showing signs of a hormonal imbalance that can indicate the presence of Polycystic Ovarian Syndrome, a disorder that develops in 5 to 10 percent of women today, according to the National Institutes of Health.
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"Time is brain"
Barnes-Jewish named primary stroke center
Sept. 6,
2005 -- Barnes-Jewish has been certified as a Primary Stroke Center — the first hospital in the St. Louis area to receive the honor. Abdullah Nassief, Washington University neurologist and director of the stroke center, comments.
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Improving health
Community Wellness Program keeps St. Louis healthy
Aug. 25,
2005 -- Obese children and frail older adults in underserved areas in St. Louis are getting help from a new initiative called the Community Wellness Program (CWP), a collaboration between Barnes-Jewish Hospital and Washington University School of Medicine's Division of Geriatric and Nutritional Science.
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Additional Background: Klein, the Danforth Professor of Medicine and Nutritional Sciences, also is director of the Division of Geriatrics and Nutritional Sciences at the School of Medicine. He directs the University's Center for Human Nutrition, and is associate program director of the University's General Clinical Research Center and medical director of both the Washington University Weight Management Center and the Barnes-Jewish Hospital Nutrition Support Service. Klein has developed several new clinical and research programs aimed at prevention and therapy for nutrition-related diseases. Klein has developed several new clinical and research programs aimed at prevention and therapy for nutrition-related diseases. In his role with the Washington University Weight Management Center, Klein helps provide patients with long-term therapy for obesity. Current clinical research includes assessment of diet comosition on weight loss and the regulation of fat metabolism in obesity.
Affiliated with Barnes-Jewish Hospital and St. Louis Children's Hospital, members of BJC HealthCare.
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