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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
Director, Genome Sequencing Center
Expertise: Large-scale genome sequencing and analysis, gene sequencing, chromosome, Human Genome Project
Bio: Under the leadership of Richard Wilson and other experts, the Genome Sequencing Center (GSC) has become an internationally renowned center for innovative high-speed sequencing of genetic material. Researchers at the GSC produced the initial analyses of more than 20 percent of the human genome and were primarily responsible for the first detailed studies of human chromosomes 2, 4, 7 and Y. GSC researchers also produced the first completed genomes of a multicellular organism (the microscopic worm C. elegans) and land plant (the flowering mustard Arabidopsis thaliana) and are significant contributors to many other important genomes, including the chicken, chimpanzee and mouse genomes.
Education:
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Ph.D. in Chemistry at University of Oklahoma
| News Stories & Tip Sheets: |
Showing Stories 1 through 5 of 16.
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DNA cornucopia
Amaizeing: Corn genome decoded
Nov. 19,
2009 --
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| Iowa State |
In recent years, scientists have decoded the DNA of humans and a menagerie of creatures but none with genes as complex as a stalk of corn, the latest genome to be unraveled. A team of scientists led by The Genome Center at the School of Medicine published the completed corn genome in the Nov. 20 journal Science, an accomplishment that will speed efforts to develop better crop varieties to meet the world's growing demands for food, livestock feed and fuel.
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What separates men from mice?
Of Mice and Men: Scientists unveil complete genome sequence of the mouse
May 29,
2009 -- Genetically speaking, what distinguishes a man from a mouse? U.S. and European scientists provide the answer in this week's PLoS Biology. They have described the finished genome sequence of the mouse, which, after the human, is only the second mammal to have its complete genome decoded.
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Tracing cancer to its genetic roots
Washington University scientists first to sequence genome of cancer patient
Nov. 5,
2008 --
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| Acute myelogenous leukemia cells |
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For the first time, scientists have decoded the complete DNA of a cancer patient and traced her disease - acute myelogenous leukemia - to its genetic roots. A large research team at the Genome Sequencing Center and the Siteman Cancer Center at the School of Medicine sequenced the genome of the patient - a woman in her 50s who ultimately died of her disease - and the genome of her leukemia cells, to identify genetic changes unique to her cancer.
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Personalizing lung cancer treatment
Scientists find new genes linked to lung cancer
Oct. 22,
2008 -- Working as part of a multi-institutional collaboration, scientists at the School of Medicine have assembled the most complete catalog to date of the genetic changes underlying the most common form of lung cancer. The research, published Oct. 23 in Nature, helps lay the foundation for more personalized diagnosis and treatment of a disease that is the leading cause of U.S. cancer deaths.
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New genetic links to common form of brain cancer
Team of scientists uncovers genetic mutations linked to aggressive brain tumor
Sept. 4,
2008 -- Scientists at the School of Medicine, working as part of a large-scale federally funded research collaboration, have discovered new genetic mutations and molecular pathways underlying glioblastoma, the most common form of brain cancer and the most aggressive.
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Showing Stories 1 through 5 of 16.
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New Clues to Sex Anomalies in How Y Chromosomes Are Copied
The New York Times
Sept. 16,
2009 -- Article looks at another David Page contribution to the science of genetics.
A weakness in the system that allows the male Y chromosome to protect and repair itself can explain an array of genetic sexual disorders.:
The palindromes were discovered in 2003 when the Y chromosome's sequence of bases, represented by the familiar letters G, C, T and A, was first worked out by David Page of the Whitehead Institute and colleagues at the DNA sequencing center at WUSTL medical school.
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Genome of Leukemia Patient Reveals Common Mutations
U.S. News & World Report online
and 13 others
Aug. 6,
2009 -- Decoding the genome of a man with acute myeloid leukemia revealed genetic mutations that may be common among other cancer patients. The findings could help scientists understand the genetic basis of cancer. Includes comments by WUSTL researchers Richard Wilson, co-author and director of the Genome Center, and Timothy Ley, study senior author and medicine professor.
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Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure
U.S. News & World Report online
July 1,
2009 -- WUSTL biochemists Elaine Mardis and Richard Wilson helped decode the human genome and are now working to find genetic mutations associated with acute myeloid leukemia.
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