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Director, Genome Sequencing Center
Expertise: Large-scale genome sequencing and analysis, gene sequencing, chromosome, Human Genome Project
Bio: Under the leadership of Richard Wilson and other experts, the Genome Sequencing Center (GSC) has become an internationally renowned center for innovative high-speed sequencing of genetic material. Researchers at the GSC produced the initial analyses of more than 20 percent of the human genome and were primarily responsible for the first detailed studies of human chromosomes 2, 4, 7 and Y. GSC researchers also produced the first completed genomes of a multicellular organism (the microscopic worm C. elegans) and land plant (the flowering mustard Arabidopsis thaliana) and are significant contributors to many other important genomes, including the chicken, chimpanzee and mouse genomes.
Education:
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Ph.D. in Chemistry at University of Oklahoma

New Clues to Sex Anomalies in How Y Chromosomes Are Copied

Article looks at another David Page contribution to the science of genetics.
A weakness in the system that allows the male Y chromosome to protect and repair itself can explain an array of genetic sexual disorders.:
The palindromes were discovered in 2003 when the Y chromosome's sequence of bases, represented by the familiar letters G, C, T and A, was first worked out by David Page of the Whitehead Institute and colleagues at the DNA sequencing center at WUSTL medical school.

References:
- Sept. 15,
2009
—
New Clues to Sex Anomalies in How Y Chromosomes Are Copied
in the The New York Times
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Genome of Leukemia Patient Reveals Common Mutations

Decoding the genome of a man with acute myeloid leukemia revealed genetic mutations that may be common among other cancer patients. The findings could help scientists understand the genetic basis of cancer. Includes comments by WUSTL researchers Richard Wilson, co-author and director of the Genome Center, and Timothy Ley, study senior author and medicine professor.

References:
- Aug. 5,
2009
—
Genome of Leukemia Patient Reveals Common Mutations
in the U.S. News & World Report online
and 13 others.
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Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure

WUSTL biochemists Elaine Mardis and Richard Wilson helped decode the human genome and are now working to find genetic mutations associated with acute myeloid leukemia.

References:
- June 30,
2009
—
Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure
in the U.S. News & World Report online
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Experts Decode Cancer Patient's Genes, Seeking Treatment Clues

For the first time, researchers have decoded all the genes of a person with cancer and found a set of mutations that might have caused the disease or aided its progression. Includes comments by Richard Wilson, senior study author and director of WUSTL's Genome Sequencing Center, and WUSTL hematologist Timothy Ley, director of the study.

References:
- Nov. 6,
2008
—
Experts Decode Cancer Patient's Genes, Seeking Treatment Clues
in the The New York Times
and 57 others.
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Looking at Genome of the Platypus
 Platypus looks funny from the inside too, discovers WUSTL genome sequencing team.

An international scientific team, which announced the first decoding of the platypus genome, said the findings provided "many clues to the function and evolution of all mammalian genomes," including that of humans, and should "inspire rapid advances in other investigations of mammalian biology and evolution." The research was conducted by a group of almost 100 scientists led by WUSTL genetics professor Wesley Warren.

References:
- May 8,
2008
—
Looking at Genome of the Platypus
in the The New York Times
and 3 others.
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Platypus Genome Reveals Secrets of Mammal Evolution

Decoding the platypus genome has long been an important goal for biologists seeking to understand the origins of mammal evolution. That goal was reached by the team of project leader, WUSTL's Wesley Warren.

References:
- May 7,
2008
—
Platypus Genome Reveals Secrets of Mammal Evolution
in the National Geographic News
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Platypus Is Even More Strange Than It Looks

NPR's Joe Palca reports that scientists have now completed a draft DNA sequence of the platypus genome that reveals reptilian and mammalian elements. WUSTL genetics professor Richard Wilson, who directed the platypus genome project at WUSTL, comments.

References:
- May 7,
2008
—
Platypus Is Even More Strange Than It Looks
in the NPR All Things Considered
and 1 others.
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Group says it has mapped corn genome

Richard Wilson, director of WUSTL's Genome Sequencing Center, comments on the successful mapping of the corn genome.

References:
- Feb. 26,
2008
—
Group says it has mapped corn genome
in the Associated Press
and 76 others.
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WUSTL to study corn's genetic code
 WUSTL to study corn's genetic code

WUSTL Genome Sequencing Center researchers will lead a project to decipher the genetic code of corn, which they say should provide the knowledge leading to better corn yields.
Lead investigator Richard Wilson comments.

References:
- Nov. 16,
2005
—
Washington U. to Study Corn's Genetic Code
in the CBS News
- Nov. 16,
2005
—
WU wins a grant to map genetics of corn
in the St. Louis Post-Dispatch
and 42 others.
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Field Museum gets a new superstar

The skeleton of Clint the chimp, whose blood sample was used to map the chimpanzee genome, will reside at the Chicago Field Museum. The chimp died recently of heart failure at the age of 24. His remains will be safeguarded for future research.
WUSTL geneticist Richard Wilson, who participated in the chimp project, comments.

References:
- Sept. 6,
2005
—
Field Museum gets a new superstar
in the Chicago Tribune
and 15 others.
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Man, Chimp Separated by Dab of DNA

Article on the reports published in Nature and Science magazines that an international team of scientists, including WUSTL's Genome Sequencing Center director Richard Wilson and colleague LaDeana Hillier, have finished sequencing the genome of the chimp. The comparison of genetic blueprints shows that just a handful of mutations account for the vast differences between the species. Scientists say the results provide a roadmap for studying diseases and the mechanisms by which humans evolved into the dominant species of Earth.

References:
- Sept. 1,
2005
—
In Chimpanzee DNA, Signs of Y Chromosome's Evolution
in the New York Times
- Sept. 1,
2005
—
Man, Chimp Separated by Dab of DNA
in the Los Angeles Times
- Sept. 1,
2005
—
Washington U. had major role in chimp genome sequencing
in the St. Louis Post-Dispatch
and 55 others.
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Newly deciphered chicken genome should shed light on human DNA
 Newly deciphered chicken genome should shed light on human DNA

The School of Medicine's Richard Wilson says that the human and chicken genomes have been evolving separately for about 310 million years, making the chicken genome a 'sweet spot' on the evolutionary tree for comparisons shedding light on the human genome.

References:
- Dec. 8,
2004
—
Newly deciphered chicken genome should shed light on human DNA
in the Associated Press Worldstream
and 93 others.
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