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Director, Genome Sequencing Center
Expertise: Large-scale genome sequencing and analysis, gene sequencing, chromosome, Human Genome Project
Bio: Under the leadership of Richard Wilson and other experts, the Genome Sequencing Center (GSC) has become an internationally renowned center for innovative high-speed sequencing of genetic material. Researchers at the GSC produced the initial analyses of more than 20 percent of the human genome and were primarily responsible for the first detailed studies of human chromosomes 2, 4, 7 and Y. GSC researchers also produced the first completed genomes of a multicellular organism (the microscopic worm C. elegans) and land plant (the flowering mustard Arabidopsis thaliana) and are significant contributors to many other important genomes, including the chicken, chimpanzee and mouse genomes.
Education:
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Ph.D. in Chemistry at University of Oklahoma
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DNA cornucopia
Amaizeing: Corn genome decoded
Nov. 19,
2009 --
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| Iowa State |
In recent years, scientists have decoded the DNA of humans and a menagerie of creatures but none with genes as complex as a stalk of corn, the latest genome to be unraveled. A team of scientists led by The Genome Center at the School of Medicine published the completed corn genome in the Nov. 20 journal Science, an accomplishment that will speed efforts to develop better crop varieties to meet the world's growing demands for food, livestock feed and fuel.
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What separates men from mice?
Of Mice and Men: Scientists unveil complete genome sequence of the mouse
May 29,
2009 -- Genetically speaking, what distinguishes a man from a mouse? U.S. and European scientists provide the answer in this week's PLoS Biology. They have described the finished genome sequence of the mouse, which, after the human, is only the second mammal to have its complete genome decoded.
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Tracing cancer to its genetic roots
Washington University scientists first to sequence genome of cancer patient
Nov. 5,
2008 --
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| Acute myelogenous leukemia cells |
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For the first time, scientists have decoded the complete DNA of a cancer patient and traced her disease - acute myelogenous leukemia - to its genetic roots. A large research team at the Genome Sequencing Center and the Siteman Cancer Center at the School of Medicine sequenced the genome of the patient - a woman in her 50s who ultimately died of her disease - and the genome of her leukemia cells, to identify genetic changes unique to her cancer.
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Personalizing lung cancer treatment
Scientists find new genes linked to lung cancer
Oct. 22,
2008 -- Working as part of a multi-institutional collaboration, scientists at the School of Medicine have assembled the most complete catalog to date of the genetic changes underlying the most common form of lung cancer. The research, published Oct. 23 in Nature, helps lay the foundation for more personalized diagnosis and treatment of a disease that is the leading cause of U.S. cancer deaths.
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New genetic links to common form of brain cancer
Team of scientists uncovers genetic mutations linked to aggressive brain tumor
Sept. 4,
2008 -- Scientists at the School of Medicine, working as part of a large-scale federally funded research collaboration, have discovered new genetic mutations and molecular pathways underlying glioblastoma, the most common form of brain cancer and the most aggressive.
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Duck-billed DNA
Platypus genome explains animal's peculiar features; holds clues to evolution of mammals
May 7,
2008 --
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| Nicole Duplaix/Getty Images |
| The platypus genome explains the creature's fascinating features, from mammals, reptiles and birds. |
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The duck-billed platypus: part bird, part reptile, part mammal — and the genome to prove it. An international consortium of scientists, led by the School of Medicine, has decoded the genome of the platypus, showing that the animal's peculiar mix of features is reflected in its DNA. An analysis of the genome, published today in the journal Nature, can help scientists piece together a more complete picture of the evolution of all mammals, including humans.
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Kernel of truth for corn
Washington University unveils draft sequence of corn genome
Feb. 25,
2008 --
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| Richard K. Wilson, Ph.D., is leading efforts to sequence the corn genome. |
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University scientists have begun to unlock the genetic secrets of corn, a crop vital to U.S. agriculture. The researchers have completed a working draft of the corn genome, an accomplishment that should accelerate efforts to develop better crop varieties to meet society's growing demands for food, livestock feed and fuel.
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In search of genetic variation
Washington University part of major effort to sequence 1,000 human genomes
Jan. 22,
2008 --
The School of Medicine will play a leading role in an international collaboration to sequence the genomes of 1,000 individuals. The ambitious 1000 Genomes Project will create the most detailed picture to date of human genetic variation and likely will identify many genetic factors underlying common diseases.
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A new look at lung cancer
Genome researchers uncover novel genetic alterations in lung cancer
Nov. 4,
2007 -- Scientists at the School of Medicine, working as part of an international team of researchers, have completed a massive effort to map the genetic changes underlying the most commonly diagnosed form of lung cancer. Their results are published in the Nov. 4 advance online issue of the journal Nature.
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Meeting massive computing needs
Data center construction will support advances in genome sequencing
Oct. 30,
2007 -- An important component of BioMed 21, the Genome Sequencing Center at Washington University in St. Louis is a gene-sequencing powerhouse and one of the four such centers in the world. It specializes in large-scale, high-throughput genome sequencing, supplying data that helps researchers at the School of Medicine identify the genetic factors that contribute to disease.
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