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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
Professor of Surgery
Expertise: Cancer genetics, cancer, DNA, genetics, gene expression
Bio: The Goodfellow laboratory is investigating the genetic alterations that underlie development of uterine endometrial cancers. Endometrial cancer is the most common gynecologic malignancy in the United States. Like many cancers, uterine endometrial cancers are hormonally- responsive tumors. The genetic defects that are associated with the phenotypic progression from normal endometrium to carcinoma are elucidated through direct examination of primary human and mouse tumor tissues and precursor lesions. The lab's efforts focus on the characterization of how changes in methylation of key regulatory sequences contribute to the cancer state, defining the inherited and acquired causes of defective DNA mismatch repair and determining how loss of DNA mismatch repair contributes to genotypic progression.
Endometrial, colon and other tumors with defective DNA mismatch repair accumulate large numbers of mutations. However, the genes that acquire mutations as a result of loss of mismatch repair remain elusive. We are attempting to determine how defective mismatch influences phenotypic and genotypic progression using a mouse model. Tumors are promoted with the synthetic estrogen, DES, in mice in which the Mlh1 DNA mismatch repair gene has been knocked out. Expression profiling in cancers and precancerous lesions provides candidate genes that are verified in mouse tumors, and their role in disease validated in human cancers.
Education:
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M.S. in Plant Pathology at University of Tennessee
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Ph.D. in Biology/Pediatrics at Queen's University
| News Stories & Tip Sheets: |
Showing 4 Stories.
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New approach to treating endometrial cancer
Breakthrough shows promise for treating endometrial cancer
Sept. 2,
2008 -- Researchers have found a potential new approach to treating endometrial cancer — a drug that was shown to be effective even against human endometrial cancer cell lines that tend to be treatment resistant. Scientists at the School of Medicine and the Translational Genomics Research Institute discovered that introducing a particular inhibitor drug can turn off cell receptors that are responsible for tumor growth.
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Accelerating treatment
Gene discovery lays groundwork for targeted therapies for endometrial cancer
May 22,
2007 -- Discovery of alterations in a gene called FGFR2 could accelerate the development of new treatments for endometrial cancer, a type of uterine cancer. Researchers at Washington University School of Medicine in St. Louis; the Translational Genomics Research Institute (TGen); the Wellcome Trust Sanger Institute, which is part of Cambridge University; and New York University School of Medicine reported the findings in the May 21, 2007, online version of the journal Oncogene.
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Fighting the good fight
Researcher works to identify genetic changes that lead to cancer
Feb. 22,
2006 --
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| Photo by Robert Boston |
| Goodfellow (right) and clinical fellow Israel Zighelbolm use gels to identify genetic mutations in cancer specimens. |
Paul J. Goodfellow, Ph.D., is in a professional war with cancer. The professor of genetics, surgery, and of obstetrics and gynecology brings an arsenal of knowledge and passion to his research battle with the formidable adversary. Using what he calls "clinical specimens," Goodfellow looks at inherited factors contributing to cancer risk.
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Live long and prosper
Doctors want to unlock secrets of the healthy
Oct. 27,
2005 -- By comparing genetic data of superbly healthy individuals to those of cancer patients, scientists at the School of Medicine hope to unlock the secrets to long, healthy lives. They're looking to develop a blood test to detect potential tumors before they begin. Learn more about the WUSM cancer genetics research led by Paul Goodfellow in this St. Louis Post-Dispatch article.
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Affiliated with Barnes-Jewish Hospital and St. Louis Children's Hospital, members of BJC HealthCare.
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