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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
Donald O. Schnuck Family Professor of Neurology
Expertise: Brain tumors, cancer genetics, neurofibromatosis, molecular genetics, neurosciences, neurology
Bio: Gutmann is the founder and director of the Neurofibromatosis Clinical Program, which is dedicated to treating the common inherited tumor predisposition syndrome, neurofibromatosis (NF). Individuals with NF have an increased risk of developing brain tumors and other cancers. As national leader in the development of genetically-modified mouse models of human cancers, he has developed mouse models of NF brain tumors. Lastly, using a team approach to translate basic science discoveries to improved clinical care for individuals with NF, Gutmann established the Washington University NF Center in 2004.
Education:
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M.D. at University of Michigan
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Ph.D. at University of Michigan
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M.S. in Human genetics at University of Michigan
| News Stories & Tip Sheets: |
Showing Stories 1 through 5 of 14.
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New drug target
Mutation linked to pediatric brain tumor may pave way for targeted treatment
Oct. 29,
2009 -- Researchers at the School of Medicine have linked mutations in a gene to a benign pediatric brain tumor, a finding that will help scientists seek drug treatments that block growth of the tumors, they report in the journal Neurology.
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Cancer: weapons and suspects
WUSTL leads study of pediatric brain tumors
Aug. 10,
2009 -- The National Cancer Institute (NCI) has awarded a five-year, $4 million grant to researchers at the School of Medicine to use genetically-engineered mice to study the origins and potential treatments of pediatric brain tumors. David H. Gutmann, the Donald O. Schnuck Family Professor of Neurology, is principal investigator of the grant, which is part of the NCI's Mouse Models of Human Cancers Consortium. He is also on staff at Barnes-Jewish and St. Louis Children's hospitals.
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Brain tumors connected to molecular make-up of cells
Brain cells' hidden differences linked to potential cancer risk
Feb. 19,
2009 -- Brain cells long lumped into the same category have hidden differences that may contribute to the formation of tumors, according to a new study from researchers at the School of Medicine. Scientists showed that brain cells known as astrocytes make use of different genes depending on what region of the mouse brain they came from. These differences are too subtle to overtly mark them as distinct cell types, but substantial enough to make it easier for the cells to multiply more in response to genetic changes that increase cancer risk.
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Surprising details about gene that affects height
Gene's newly explained effect on height may change tumor disorder treatment
Aug. 11,
2008 -- A mutation that causes a childhood tumor syndrome also impairs growth hormone secretion, researchers at the School of Medicine have found. The discovery provides new insights into an old mystery, revealing why patients with neurofibromatosis type 1 are frequently shorter than their peers. The surprising details have led scientists to consider modifying their search for treatments for the inherited disorder, which is caused by a mutation in the neurofibromin 1 (NF1) gene and is characterized by an increased risk of cancer.
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Quicker translation from mouse to human
Mouse model tightly matches pediatric tumor syndrome, will speed drug hunt
March 1,
2008 -- Frustrated by the slow pace of new drug development for a condition that causes pediatric brain tumors, a neurologist at the School of Medicine decided to try to fine-tune the animal models used to test new drugs. Instead of studying one mouse model of the disease causing the brain tumors, the laboratory of David Gutmann, M.D., Ph.D., the Donald O. Schnuck Family Professor of Neurology, evaluated three and found that one of most closely mimicked what is seen in children who develop brain tumors.
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Showing Stories 1 through 5 of 14.
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