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 | Medical News Releases > Faculty Experts at Washington University in St. Louis >
Chromalloy Professor of Renal Diseases in Medicine
Expertise: Organogenesis, organ, transplant, kidney, pancreas, diabetes, kidney failure, xenotransplant, primordia
Bio: Hammerman is a leader in the emerging field of organogenesis, which focuses on growing organs from stem cells and other embryonic cell clusters known as organ primordia. Unlike stem cells, which can become virtually any cell type, primordia are locked into becoming a particular cell type or one of a particular set of cell types that make up an organ.
Hoping to compensate for the lack of available human donor organs and to stem the tide of casualties that shortage inflicts on patients, Hammerman has been developing techniques for using embryonic pig primordia to treat diabetes and kidney failure in rats. Hammerman and colleague Sharon Rogers were the first to successfully cure diabetic rats through the transplantation of embryonic pig pancreas primodia. They have also demonstrated that kidneys grown from pig primordia can temporarily sustain rats whose original kidneys have been removed.
WUSTL Contact Information:
Education:
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M.D. at Washington University
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A.B. at Washington University
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Inching closer to a cure
Cross-species transplant in rhesus macaques is step toward diabetes cure for humans
Oct. 18,
2007 --
In a new study with an eye on curing diabetes, senior investigator Marc Hammerman and a group of WUSM scientists successfully transplanted embryonic pig pancreatic cells destined to produce insulin into diabetic macaque monkeys - all without the need for risky immune suppression drugs that prevent rejection. The transplanted cells, known as primordia, are in the earliest stages of developing into pancreatic tissues. Within several weeks of the transplants, the cells became engrafted, or established, within the three rhesus macaque monkeys that received them. The cells also released pig insulin in response to rising blood glucose levels, as would be expected in healthy animals and humans.
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Fighting a 'devastating illness'
$5.7 million to fund new kidney disease research center
Aug. 6,
2007 -- A $5.7 million grant will establish a new center for kidney disease research at the School of Medicine. Directed by Marc R. Hammerman, the Chromalloy Professor of Renal Diseases in Medicine, the center will investigate the underlying causes of kidney disease to speed the development of new treatments. The center's funding comes from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), one of the National Institutes of Health (NIH).
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Cures for diabetes
Transplant cures rats' type 2 diabetes without immune suppression drugs
Sept. 12,
2006 -- An approach proven to cure a rat model of type 1 or juvenile-onset diabetes also works in a rat model of type 2 or adult-onset diabetes, according to a new report from researchers at the School of Medicine.
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