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Goate

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• B.Sc. in Biochemistry at University of Bristol (England)
• D.Phil. in Pathology at Linacre College, University of Oxford

News Stories & Tip Sheets:

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Genetic marker Gene variation linked to earlier onset of Alzheimer's symptoms (http://mednews.wustl.edu/news/page/normal/11867.html) June 9, 2008 -- Goate Download Investigators at the School of Medicine have identified a genetic variation associated with an earlier age of onset in Alzheimer's disease. Unlike genetic mutations previously linked to rare, inherited forms of early-onset Alzheimer's disease — which can strike people as young as their 30s or 40s — these variants influence an earlier presentation of symptoms in people affected by the more common, late-onset form of the disease.

Memory images Older adult volunteers needed for memory imaging study (http://mednews.wustl.edu/news/page/normal/8608.html) Jan. 24, 2007 -- Investigators at the School of Medicine are conducting a study to investigate factors related to memory in older adults. They are seeking healthy volunteers between 70 and 75 years of age who have siblings also willing to participate. Study participants will undergo a magnetic resonance imaging (MRI) scan to determine the structure of the brain and a positron emission tomography (PET) scan to analyze amyloid levels in the brain.

Zeroing in on a gene Region of DNA strongly associated with Alzheimer’s disease (http://mednews.wustl.edu/news/page/normal/6353.html) Jan. 10, 2006 -- An international team of researchers, led by investigators at the School of Medicine, are zeroing in on a gene that increases risk for Alzheimer's disease. They have identified a region of chromosome 10 that appears to be involved in risk for the disease that currently affects an estimated 4.5 million Americans.

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Since that initial discovery, Goate and colleagues have identified mutations in two other genes that cause Alzheimer's disease. Her current work is focused upon two issues: gaining a greater understanding of the pathogenic mechanisms of these disease-causing mutations and identifying novel genetic risk factors for late onset Alzheimer's disease. Goate's laboratory also studies genes that might make people more susceptible to alcoholism.

Related Information Related Links: • Medical School Web site (http://medschool.wustl.edu/) • Department of Psychiatry Web site (http://www.psychiatry.wustl.edu) • Department of Genetics Web site (http://www.genetics.wustl.edu/) • Goate's Web page (http://dbbs.wustl.edu/dbbs/website.nsf/RIB/04B8775A1A6E784486256D4E005B2D0F) Related Groups: