| David H. Gutmann |
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 Michael Purdy Senior Medical Sciences Writer purdym@wustl.edu (314) 286-0122 |
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| Surprising details about gene that affects height Gene's newly explained effect on height may change tumor disorder treatment (http://mednews.wustl.edu/news/page/normal/12134.html) Aug. 11, 2008 -- A mutation that causes a childhood tumor syndrome also impairs growth hormone secretion, researchers at the School of Medicine have found. The discovery provides new insights into an old mystery, revealing why patients with neurofibromatosis type 1 are frequently shorter than their peers. The surprising details have led scientists to consider modifying their search for treatments for the inherited disorder, which is caused by a mutation in the neurofibromin 1 (NF1) gene and is characterized by an increased risk of cancer. |
| Quicker translation from mouse to human Mouse model tightly matches pediatric tumor syndrome, will speed drug hunt (http://mednews.wustl.edu/news/page/normal/11186.html) March 1, 2008 -- Frustrated by the slow pace of new drug development for a condition that causes pediatric brain tumors, a neurologist at the School of Medicine decided to try to fine-tune the animal models used to test new drugs. Instead of studying one mouse model of the disease causing the brain tumors, the laboratory of David Gutmann, M.D., Ph.D., the Donald O. Schnuck Family Professor of Neurology, evaluated three and found that one of most closely mimicked what is seen in children who develop brain tumors. |
| Shaping young minds Cancer gene drives pivotal decision in early brain development (http://mednews.wustl.edu/news/page/normal/10562.html) Nov. 12, 2007 -- A gene linked to pediatric brain tumors is an essential driver of early brain development, researchers at the School of Medicine have found. The study, published in October in Cell Stem Cell, reveals that the neurofibromatosis 1 (NF1) gene helps push stem cells down separate paths that lead them to become two major types of brain cells: support cells known as astrocytes and brain neurons. |
| Tumor trick probed Study suggests existing drugs may be useful in treating brain tumors (http://mednews.wustl.edu/news/page/normal/10330.html) Oct. 15, 2007 -- Scientists have shown how developing brain tumors can turn an encounter with a signaling molecule from a fatal experience for the tumor cells into a cue for their own growth and multiplication. Researchers at the School of Medicine found the transformation relies on at least two other molecules that can be modified with existing drugs, opening the possibility that they may be able to use the established drugs to treat brain tumors. |
| Slowing tumor growth Brain tumors coax important support from nearby immune system cells (http://mednews.wustl.edu/news/page/normal/9258.html) April 11, 2007 -- Developing brain tumors can coax assistance from nearby cells known as microglia, according to a new study from scientists at the School of Medicine. The researchers have identified one protein made by microglia that helps accelerate tumor growth and are looking for others. |
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